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This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Drugs

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Drugs

December 2018

Pembrolizumab (Keytruda) for relapsed/refractory classical Hodgkin lymphoma

Pembrolizumab is a medicinal product that is being investigated as treatment for patients with relapsed or refractory classical Hodgkin lymphoma (cHL). Hodgkin lymphoma is a type
of cancer of the lymphatic system and it is the most common type. The condition is called relapsed or refractory when it recurs after a period of improvement or when it does not
respond to treatment. The most common symptom of Hodgkin lymphoma is a swelling in the neck, armpit or groin.

Drugs

December 2018

Avacopan in addition to standard of care for ANCA-associated vasculitis

Avacopan is an orally-administered medicinal product that targets specific proteins that contribute to the inflammation of small blood vessels in ANCA-vasculitis. Avacopan has been shown to be of benefit as an alternative to glucocorticoids for the induction of remission in ANCA-associated vasculitis. It has fewer side-effects than glucocorticoids, and may also improve the preservation of kidney function. If licensed, avacopan in addition to standard of care therapies could offer an option for inducing and sustaining remission in patients with ANCA-associated vasculitis

Drugs

December 2018

Brentuximab vedotin in addition to cyclophosphamide, doxorubicin, and prednisolone (CHP) for CD30+ mature T-cell lymphoma

Brentuximab vedotin is a monoclonal antibody cancer treatment medicine that lead to cell death selectively in CD30-expressing tumour cells. Brentuximab vedotin in addition to CHP will offer an additional treatment option for patients with CD30+ mature T-cell lymphoma.

Drugs

November 2018

Sutimlimab for primary cold agglutinin disease

Sutimlimab is a first-in-class monoclonal antibody in development for the treatment of cold agglutinin disease, a rare form of autoimmune haemolytic anaemia, caused by cold-reacting autoantibodies. These antibodies bind to red blood cell membranes and destroy them, leading to anaemia. Symptoms include chronic debilitating fatigue, acrocyanosis, shortness of breath and other anaemia-related symptoms, leading to a poor quality of life and increased health resource utilization. In chronic cold agglutinin disease, the patient is more symptomatic during winter months. Therapeutic options may range from using warm clothing and avoiding exposure to cold weather to blood transfusions and chemotherapy.

Drugs

November 2018

Atezolizumab in combination with nab-paclitaxel as neoadjuvant treatment for early stage triple-negative breast cancer

Atezolizumab is a cancer medicine that enhances T-cell (part of the immune system) activity against tumours. Nab-paclitaxel is a chemotherapy that combines the chemotherapy drug paclitaxel with a protein called albumin. It inhibits cell growth by preventing cell division. The combination may offer an additional neoadjuvant treatment option to improve clinical efficacy in the treatment of people with early stage TNBC, an aggressive disease with no approved targeted therapy.

Drugs

November 2018

Edaravone for amyotrophic lateral sclerosis

Edaravone as an intravenous injection is in clinical development for people with amyotrophic lateral sclerosis (ALS). ALS is a neurological condition that affects nerve cells in the brain and
spinal cord. It results in gradual weakness and wasting of muscles of the body. Respiratory muscles are involved as the disease progresses, leading to shortness of breath and ultimately
death. Little is known about the cause of the disease, and there is currently no cure.

Drugs

November 2018

Human plasminogen for hypoplasminogenemia

Plasminogen (human) as intravenous infusion is in clinical development for people with hypoplasminogenemia. Hypoplasminogenemia is an ultra-rare, chronic, genetic condition associated with inflamed growths on the mucous membranes, the moist tissues that line body openings such as the eye, mouth, nasopharynx, trachea, and female genital tract. The growths are caused by the deposition of fibrin (a protein involved in blood clotting) and by inflammation. Growths can lead to severe medical problems including vision loss, ulcers of the gastrointestinal tract, and breathing difficulties caused by obstruction of the airway.

Drugs

November 2018

Polatuzumab vedotin in combination with rituximab and bendamustine for the treatment of diffuse large B-cell lymphoma

Polatuzumab vedotin is a first-in-class antibody drug specifically developed for the treatment of cancers that affect the blood and lymph system. It is a monoclonal antibody that acts by selectively binding to CD79b, a protein which is abundantly expressed on the surface of B-cells. It is administered as an intravenous infusion, absorbed by the cancer cells and the chemotherapy agent linked to the antibody releases inside the cancer cells and destroys them. Adding polatuzumab vedotin to bendamustine with rituximab may improve effectiveness in patients whose disease had come back or in whom other treatment had not worked well enough.

Drugs

November 2018

Angiotensin II acetate (Giapreza) for vasopressor resistant hypotension due to distributive shock

Angiotensin II acetate is in clinical development for the treatment of catecholamine and/or vasopressin resistant hypotension due to distributive shock. Shock is a critical condition in which blood pressure drops so low that the brain, kidneys and other vital organs cannot receive enough blood flow to function properly. Distributive shock is the most common type of shock that is most commonly caused by bacterial or fungal infection (septic shock) or allergic reaction (anaphylactic shock). Severe shock is usually treated with drugs called catecholamines or vasopressin. Shock that does not respond to treatment with these drugs is resistant shock.

Drugs

November 2018

Ranibizumab for proliferative and non-proliferative diabetic retinopathy

Ranibizumab as intravitreal injections is in clinical development for the treatment of diabetic retinopathy in both its proliferative and non-proliferative forms. Diabetic retinopathy, is a disease that affect the retinas and other parts of the inner eye. It is a chronic progressive condition of the retinal blood vessels due to prolonged raised blood glucose. When new blood vessels and scar tissue form on the retina causing bleeding within the eye and loss of vision, it is called proliferative diabetic retinopathy.

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