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This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Drugs > Acalabrutinib for relapsed/refractory Chronic lymphocytic leukaemia

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Acalabrutinib for relapsed/refractory Chronic lymphocytic leukaemia

Drugs

Cancer and Palliative Care

February 2019


Acalabrutinib is a novel oral anti-cancer drug in clinical development for people with relapsed or refractory (R/R) chronic lymphocytic leukaemia (CLL) who have previously been treated (second line or greater). CLL is a type of cancer in which too many white blood cells are produced. As these cells develop abnormally, they are unable to function and fight infection and stop the production of healthy blood cells. The disease is chronic and develops slowly. R/R CLL means the cancer has come back after treatment and reaching remission, or the cancer has failed to respond to treatment. Treatment options for R/R CLL include targeted therapy drugs, chemotherapy, radiation therapy or surgery.
Acalabrutinib works by blocking a specific enzyme referred to as Bruton’s Tryrosine Kinase, to slow the build-up of cancerous cells in CLL, thereby delaying or stopping the progression of the disease. The Bruton’s Tryrosine Kinase enzyme has been identified as an important therapeutic target for the treatment of CLL. Acalabrutinib is thought to be a more selective and irreversible blocker of this enzyme and is specifically designed to improve on the safety and efficacy of first generation inhibitors. Acalabrutinib has demonstrated encouraging results in clinical trials and may offer an effective treatment option for R/R CLL patients who have received other previous treatment.

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