Ovarian cancer is the sixth most common cancer in women in the UK. The ovaries are a pair of small organs located in the lower abdomen and are part of the female reproductive system. Usually women who have been through menopause and aged 65 years and over are more likely to be affected by ovarian cancer. The exact cause is not known but most cases are caused by gene changes that develop during a woman’s life and are not inherited. The main treatment options for ovarian cancer are surgery and chemotherapy. Most patients with ovarian cancer are diagnosed at an advanced stage and have a combination of both surgery and chemotherapy. Chemotherapy may be prescribed before and/or after surgery. Chemotherapy before surgery is called ‘neoadjuvant chemotherapy’.
AT406 is a medicine under development to be added to standard neoadjuvant chemotherapy for newly diagnosed advanced ovarian cancer. AT406 is a small molecule that induces cancer cell death through a dual mode of action. If licensed, AT406 may offer an additional neoadjuvant treatment option for patients with epithelial ovarian cancer especially those who develop drug resistance and relapse to other standard chemotherapy.
Nivolumab is a type of immunotherapy that is currently licensed in the UK for the treatment of several types of advanced cancers such as melanoma, non‐small cell lung cancer, and kidney cancer. It blocks a protein called programmed death-1 (PD-1), which is found on the surface of a type of immune cells called T-cells. Blocking PD-1 stimulates the T-cells to kill the cancer cells. Temozolomide in combination with radiotherapy is currently licensed in the UK for newly diagnosed glioblastoma in adults. The addition of nivolumab to temozolomide and radiotherapy will potentially offer an additional first line treatment option for adult patients who are newly diagnosed MGMT-methylated glioblastoma.