Atezolizumab in addition to cobimetinib and vemurafenib is in development for the treatment of BRAF mutated metastatic melanoma. Melanoma is a type of skin cancer which arises from the pigment cells (melanocytes) in the skin and is the most aggressive and life-threatening form of skin cancer. BRAF is a type of gene that drives rapid tumour growth and approximately half of all melanomas have mutations in the BRAF gene. Factors associated with a higher risk of developing melanoma include fair skin, exposure to sunlight and other sources of ultraviolet energy, and a history of sunburn or moles.
Atezolizumab is a type of immunotherapy that helps the body’s immune system attack the cancer and interferes with the ability of tumour cells to grow and spread. Cobimetinib and vemurafenib are targeted therapies that block specific pathways to stop the growth of tumour cells in BRAF mutated melanoma. The addition of atezolizumab to cobimetinib and vemurafenib has the potential to optimize the sequencing of targeted therapy and immunotherapy for patients with BRAF mutant metastatic melanoma.
Brigatinib is a medicinal product that is being developed for the treatment of patients with locally advanced or metastatic ALK-positive non-small cell lung cancer (NSCLC) whose disease have progressed following treatment with alectinib or ceritinib. NSCLC is the most common type of lung cancer although a small proportion of NSCLC patients have a rearrangement in the ALK gene. Locally advanced or metastatic cancer means cancer has spread outside the lungs where it started, to other parts of the body and cannot be cured. Current treatment with drugs such as alectinib or ceritinib are effective in slowing the disease and helping patients to live longer, although some patients eventually develop treatment resistance and will require other therapies.