logo
Menu

This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Drugs > Bevacizumab (Avastin) in combination with trastuzumab and docetaxel for breast cancer, HER2-positive, metastatic – first line

< Back

Bevacizumab (Avastin) in combination with trastuzumab and docetaxel for breast cancer, HER2-positive, metastatic – first line

Drugs

Cancer and Palliative Care

August 2010


Bevacizumab (Avastin; anti-VEGF monoclonal antibody; R 435; RG435; rhuMAb- VEGF) is a humanised anti-vascular endothelial growth factor (VEGF) monoclonal antibody that inhibits VEGF induced signalling and VEGF driven angiogenesis. This reduces vascularisation of tumours, thereby inhibiting tumour growth. The combination of bevacizumab, trastuzumab (HER2 inhibitor) and docetaxel (mitosis inhibitor), is intended to be used for the treatment of breast cancer with over expression of human epidermal growth factor receptor 2 (HER2). Bevacizumab is administered by IV infusion at 15mg/kg every 3 weeks in combination with trastuzumab (8mg/kg loading dose, thereafter 6mg/kg every 3 weeks) and docetaxel (100mg/m2 every 3 weeks) until disease progression.

Innovation Observatory Voice 0

Leave a Reply

Your email address will not be published. Required fields are marked *

Post Comment

PDF Report



 

Connect to the Innovation Observatory

Twitter

Load More Related Posts

Get Alerts