Bevacizumab (Avastin) in combination with trastuzumab and docetaxel for breast cancer, HER2-positive, metastatic – first line
Bevacizumab (Avastin; anti-VEGF monoclonal antibody; R 435; RG435; rhuMAb- VEGF) is a humanised anti-vascular endothelial growth factor (VEGF) monoclonal antibody that inhibits VEGF induced signalling and VEGF driven angiogenesis. This reduces vascularisation of tumours, thereby inhibiting tumour growth. The combination of bevacizumab, trastuzumab (HER2 inhibitor) and docetaxel (mitosis inhibitor), is intended to be used for the treatment of breast cancer with over expression of human epidermal growth factor receptor 2 (HER2). Bevacizumab is administered by IV infusion at 15mg/kg every 3 weeks in combination with trastuzumab (8mg/kg loading dose, thereafter 6mg/kg every 3 weeks) and docetaxel (100mg/m2 every 3 weeks) until disease progression.