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This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Drugs > Brentuximab vedotin in addition to cyclophosphamide, doxorubicin, and prednisolone (CHP) for CD30+ mature T-cell lymphoma

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Brentuximab vedotin in addition to cyclophosphamide, doxorubicin, and prednisolone (CHP) for CD30+ mature T-cell lymphoma

Drugs

Cancer and Palliative Care

December 2018


Brentuximab vedotin in addition to cyclophosphamide, doxorubicin, prednisolone (CHP) as intravenous infusion is in development for the treatment of CD30+ mature T-cell lymphoma also known as peripheral T cell lymphoma (PTCL), a subtype of non-Hodgkins lymphoma. PTCL is a group of aggressive and fast growing lymphomas that develop from mature white blood cells called T-cells and natural killer (NK) cells. If the lymphoma cells express a protein called CD30, it is described as CD30+. In most cases, it is not known what causes T-cell lymphoma. Symptoms vary depending the type of T-cell lymphoma and where it develops. Often, the first symptom of lymphoma is a painless swelling of a lymph node or a group of lymph nodes. Clinical outcomes out of the current standard of care for PTCL are insufficient and there are still unmet needs for a new therapy.
Brentuximab vedotin is a monoclonal antibody cancer treatment medicine that lead to cell death selectively in CD30-expressing tumour cells. Brentuximab vedotin in addition to CHP will offer an additional treatment option for patients with CD30+ mature T-cell lymphoma.

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