Burosumab is in clinical development for the treatment of adults with tumour-induced osteomalacia (TIO). TIO is a rare disease where an overproduction of FGF23 leads to renal phosphate wasting and low levels of phosphate and vitamin D in the body. This causes weakening (or softening) of bones. Main symptoms include bone pain, muscle weakness/fatigue and fractures and without a timely diagnosis, TIO can lead to a significant decrease in quality of life, severe functional impairment and even prostration.
Burosumab is administered by subcutaneous injection. Burosumab is designed to recognise and attach to a protein called FGF23. By attaching to the FGF23 protein, burosumab blocks its activity, thus restoring phosphate and vitamin D levels by achieving phosphate homeostasis. If licensed, burosumab will provide a treatment option for TIO.
Dostarlimab in addition to carboplatin and paclitaxel is in developmentfor recurrent or primary advanced endometrial cancer. Endometrial (uterine) cancer is cancer of the lining of the womb. Recurrent cancer is cancer that has come back after treatment. Advanced cancer is cancer that cannot normally be cured or controlled. Endometrial cancer is characterised by abnormal vaginal …