Non‐small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for about ninety per cent of lung cancers in the UK. A small proportion of NSCLC tumours have a genetic change in a gene called c‐METexon14. When NSCLC tumours have advanced or spread to other organs there are very limited treatments available.
Crizotinib is an anticancer drug that can be taken up to twice a day orally as capsules. Crizotinib works by blocking the growth and spread of cancer cells that have c‐METexon14 changes to other parts of the body. Crizotinib is already approved for the treatment of a subtype of advanced NSCLC with a different genetic change (ALK mutations) in people that have been previously treated with chemotherapy. If approved for this new indication, crizotinib has the potential to prolong survival for patients with NSCLC and c‐MET gene alteration that have advanced or spread to other organs, for which no other treatment is available apart from best supportive care.
Pembrolizumab is a medicinal product that is being investigated as treatment for patients with relapsed or refractory classical Hodgkin lymphoma (cHL). Hodgkin lymphoma is a type
of cancer of the lymphatic system and it is the most common type. The condition is called relapsed or refractory when it recurs after a period of improvement or when it does not
respond to treatment. The most common symptom of Hodgkin lymphoma is a swelling in the neck, armpit or groin.