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This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Drugs > Durvalumab in combination with tremelimumab for unresectable hepatocellular carcinoma – first line

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Durvalumab in combination with tremelimumab for unresectable hepatocellular carcinoma – first line

Drugs

Cancer and Palliative Care

October 2019


Durvalumab in combination with tremelimumab is in clinical development for patients with unresectable hepatocellular carcinoma (HCC), the most common type of liver cancer that occurs mainly in patients with underlying chronic liver disease and cirrhosis. Unresectable HCC occurs when the cancer has spread to lymph nodes or to other organs and cannot be treated by surgery. Unresectable HCC is often diagnosed late in life and has a poor prognosis. It is a debilitating condition with many distressing symptoms, including pain, digestive problems and weight loss. The current standard of care can only slow the progression of the cancer and extend survival.
Durvalumab and tremelimumab are drugs both given through intravenous infusion that act through different pathways to stimulate the body’s immune system to fight cancerous cells. The combined effect of the two products may produce a stronger more targeted immune response against the cancer cells when compared to current treatments. If licensed durvalumab in combination with tremelimumab could provide an additional efficacious and safe treatment option for patients with unresectable hepatocellular carcinoma.

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