Doxorubicin Nanoparticles are an injectable drug made up of microscopic polymer based spheres containing the drug doxorubicin. Doxorubicin, a chemotherapy drug used to treat many types of cancer, slows or stops the growth of cancer cells by blocking an enzyme called topoisomerase 2.2 Studies on doxorubicin nanoparticles on people with advance HCC have suggested it may extend lifespan. If doxorubicin nanoparticles is licenced in the UK, it could provide a new treatment option for patients with advance HCC when other treatment options have failed, which may extend patient survival time.
Pembrolizumab in addition to platinum therapy and radiation is in clinical development for the treatment of unresectable locally advanced head and neck squamous cell carcinoma. Cancers that are collectively known as head and neck cancers usually begin in the squamous cells that line the moist, mucosal surfaces inside the head and neck (for example, inside the mouth, the nose, and the throat). The main risk factors for squamous cell carcinomas are smoking tobacco and drinking alcohol. Symptoms may include sore throat, difficulty swallowing and pain in the ears and others. Treatment options for cancer that has spread usually involve chemotherapy such as (platinum-based therapy) and/or radiotherapy and focus on relieving symptoms and prolonging life rather than curing the cancer.