Acute Lymphocytic Leukaemia (ALL) is a type of cancer affecting lymphocytes (a type of white blood cell), which results in overproduction of faulty lymphocytes. The cancer cells take over the bone marrow leading to anaemia, infection, bruising and bleeding. ALL is a rare condition, usually affecting more children than adults. Some people will not respond to treatment (refractory) or some will respond to treatment but develop ALL again (relapsed). For those with relapsed or refractory ALL, there are limited treatments available.
KTE-C19 is new type of therapy where T-cells (a type of immune white blood cell) are collected from a patient and engineered to be able to recognise molecules on the surface of cancer cells, which triggers the T-cells to attack and kill the cancer cells. KTE-C19 is given to patients by a single infusion. If KTE-C19 is licenced for use in adults with refractory/relapsed acute lymphoblastic leukaemia, it will provide an additional, cancer-specific treatment option for this population who currently have limited treatment options.
Ixazomib citrate is a novel oral medicinal product that is already licensed in the UK for the treatment of MM in patients who have received at least one prior therapy (in combination with lenalidomide and dexamethasone). Ixazomib citrate offers the potential advantage over similar medicines in its class of being more effective in its anticancer activity, less toxic (reduced side effects) and more convenient to administer (through its weekly oral dosing). If approved as maintenance therapy following stem cell transplant in newly diagnosed MM patients, ixazomib citrate has the potential to improve the success rates of treatment by improving progression free survival and overall survival as well as presenting a more convenient way of administration that allows long term administration and improvement of patients’ quality of life.