Systemic Sclerosis (SS) is a rare disease caused by the immune system attacking the tissue which lines underneath the skin and internal organs (connective tissue). The exact cause of SS is not known but it is thought to happen when immune cells attack the body’s own tissues leading to the cells in the connective tissue producing too much collagen which causes scaring and thickening of the tissue. There are 2 types of SS; limited cutaneous SS (a milder form of SS affecting only parts of the body) and diffuse cutaneous SS (a more severe form of SS which can affect the whole body). The main symptoms of diffuse cutaneous SS are hardening of the skin, acid reflux, vomiting and diarrhoea, muscular pain, weakness and cramps. The outlook for people with diffuse cutaneous SS is generally poor due to high risk of life threatening complications such as heart, lung and kidney problems.
Lenabasum is being developed for diffuse cutaneous SS as a tablet to be taken twice per day. It works by binding to immune cells and triggers a process which reduces inflammation and the scaring and thickening of tissues which usually happens in SS. If licensed, lenabasum has the potential to reduce the scaring which happens in diffuse cutaneous SS and improve symptoms.
Mepolizumab is a medicinal product currently in development as an add-on for the treatment of hypereosinophilic syndrome (HES). HES is a rare group of inflammatory disorders characterised by an overproduction of eosinophils (a type of disease-fighting white blood cell). When eosinophils infiltrate certain tissues, they can cause inflammation and organ damage which, over time, can impact patients’ day-to-day ability to function. Although any organ system can be involved in HES, the heart, central nervous system, skin, and respiratory tract are the most commonly affected.