Loxapine inhalation (Staccato Loxapine) for agitation associated with schizophrenia or bipolar-1 disorder
Loxapine inhalation (Staccato loxapine, AZ-004) is a breath-actuated hand-held disposable inhaler (the Staccato system a) which delivers a single dose of loxapine. Loxapine is a dopamine-2 and serotonin-2a receptor antagonist which acts as a tranquiliser. The exact mechanism of action of loxapine has not been established. Loxapine inhalation is intended to rapidly treat acute agitation as a substitute for currently available parenteral or oral therapies. Loxapine is administered as needed at 5mg or 10mg, up to 3 doses in a 24 hour period.