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This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Drugs > Maribavir for cytomegalovirus infections after transplant

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Maribavir for cytomegalovirus infections after transplant

Drugs

Haematology and Blood Products

November 2020


Maribavir is being developed for the treatment of cytomegalovirus (CMV) infections and the first indication expected for maribavir is for patients that are clinically refractory and/or genetically resistant to ganciclovir (GCV), valganciclovir (VGCV), cidofovir (CDV) and foscarnet (FOS). CMV is a common virus that usually only causes mild infection. In people with weakened immunity, such as transplant patients receiving treatment that reduce the activity of the immune system, CMV can cause serious infection such as pneumonia, colitis, hepatitis and retinitis. Refractory or resistant CMV in patients with impaired immunity is a long-term debilitating and life-threatening condition and associated with higher death rate in transplant patients.
Maribavir, administered orally, is thought to block the action of an enzyme of the virus called UL97 kinase. By blocking the enzyme, the medicine is expected to prevent viruses from reaching maturity, so that no new infectious viruses can be produced. If licensed, maribavir would offer an alternative treatment option for patients with CMV infections that are clinically refractory and/or genetically resistant to GCV, VGCV, CDV or FOS after stem cell or solid organ transplantation.

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