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This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Drugs > Niraparib for advanced ovarian, fallopian tube or primary peritoneal cancer – maintenance therapy

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Niraparib for advanced ovarian, fallopian tube or primary peritoneal cancer – maintenance therapy

Drugs

Cancer and Palliative Care

July 2019


Niraparib as an oral formulation is in clinical development for maintenance therapy in patients with advanced ovarian, fallopian tube or primary peritoneal cancer following response to first-line platinum-based chemotherapy. Ovarian cancer includes a group of tumours that arise from diverse types of tissue contained in the ovary. The most common type of ovarian cancer arises from epithelial cells (the outside layer of cells) on the surface of the ovary, and can often spread from the ovary to any surface within the abdominal cavity including the fallopian tubes and peritoneal cavity. Fallopian tube cancer and primary peritoneal cancer are histologically equivalent diseases to epithelial ovarian cancer.
Niraparib is a poly (ADP-ribose) polymerase (PARP) inhibitor. This means it blocks the action of enzymes called PARP-1 and PARP-2 that help to repair damaged DNA in cells when they divide to make new cells. By blocking PARP enzymes, the damaged DNA in cancer cells cannot be repaired, and the cells die. If licensed for this additional indication, niraparib will offer a maintenance treatment option for patients with advanced ovarian cancer, fallopian tube cancer, or primary peritoneal cancer following response to first-line platinum-based chemotherapy.

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