A fixed dose combination of nivolumab and relatlimab is in development for the treatment of advanced and metastatic melanoma patients that have not received previous treatment. Melanoma is a cancer of the skin, when is advanced or metastatic, the cancer has spread to other organs and tissues such as lymph nodes and the brain. Metastatic melanoma can present a range of different symptoms including lumps under the skin, swollen lymph nodes, bone pain and headaches. At this stage the cancer can’t be cured.
Nivolumab works by improving the activity of white blood cells increasing the ability of the immune system to kill cancer cells. Relatlimab has the potential to increase the immune system response and kill cancer cells. If licenced for this indication, a fixed dose combination of intravenous nivolumab and relatlimab may provide a new therapeutic option for untreated patients that shows similar adverse effects than treatment with nivolumab alone.
Nivolumab in combination with cisplatin and fluorouracil is in clinical development for patients with unresectable, advanced, recurrent or metastatic oesophageal squamous cell cancer cell carcinoma. Advanced oesophageal cancer begins in the food pipe and spreads to other parts of the body. Squamous cell cancers develop from the cells that make up the inner lining of the oesophagus. Symptoms include difficulty swallowing, persistent acid indigestion or heartburn, weight loss, pain in the throat, and chronic cough. Lifestyle factors are attributed to most oesophageal cancers, including smoking and being overweight.