Gastric cancer is cancer that starts anywhere inside the stomach or the stomach wall. Advanced gastric cancer can be locally advanced (has spread into the tissues around the stomach) or metastatic (has spread to at least one other part of the body such as the liver). Most gastric cancer cases are diagnosed at a late stage. Advanced cancers have poor prognosis and usually cannot be cured. However, it may be controlled, and symptoms can be relieved through treatment.
Nivolumab is a medicinal product that is currently licensed in the UK for the treatment of several types of advanced cancers such as melanoma, non-small cell lung cancer, and kidney cancer. It is a monoclonal antibody that acts by preventing the inhibition of T-cells (part of the body’s immune system that fight cancer) through binding to a protein called programmed cell death 1 (PD-1). Nivolumab is being developed to be used in addition to chemotherapy for the treatment of patients with advanced gastric cancer who have not had treatment previously. If licensed, nivolumab in combination with chemotherapy will offer an additional first-line treatment option for this patient group.
Pembrolizumab is a medicinal product that is being investigated as treatment for patients with relapsed or refractory classical Hodgkin lymphoma (cHL). Hodgkin lymphoma is a type
of cancer of the lymphatic system and it is the most common type. The condition is called relapsed or refractory when it recurs after a period of improvement or when it does not
respond to treatment. The most common symptom of Hodgkin lymphoma is a swelling in the neck, armpit or groin.