Nivolumab in combination with cisplatin and fluorouracil is in clinical development for patients with unresectable, advanced, recurrent or metastatic oesophageal squamous cell cancer cell carcinoma. Advanced oesophageal cancer begins in the food pipe and spreads to other parts of the body. Squamous cell cancers develop from the cells that make up the inner lining of the oesophagus. Symptoms include difficulty swallowing, persistent acid indigestion or heartburn, weight loss, pain in the throat, and chronic cough. Lifestyle factors are attributed to most oesophageal cancers, including smoking and being overweight.
Nivolumab administered by intravenous infusion, works by improving the activity of white blood cells (T-cells) thereby increasing the ability of the immune system to kill cancer cells. Cisplatin and fluorouracil are both standard chemotherapies that are used in treating many different types of advanced or metastatic cancers. If licensed, nivolumab in combination with cisplatin and fluorouracil may offer an additional treatment option for patients with advanced, recurrent, unresectable or metastatic oesophageal squamous cell carcinoma.
Olaparib is a medicinal product currently in development for the treatment of Breast Cancer Gene (BRCA)-mutated relapsed ovarian, fallopian tube or primary peritoneal cancer in patients who have received at least 2 prior platinum treatments and have progressed at least 6 months after their last platinum treatment. Ovarian cancer includes a group of tumours that arise from diverse types of tissue contained in the ovary and can often spread from the ovary to any surface within the abdominal cavity including the fallopian tubes and peritoneal cavity.