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This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Pirtobrutinib for mantle cell lymphoma

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Pirtobrutinib for mantle cell lymphoma

Cancer and Palliative Care

June 2021


Pirtobrutinib is currently in clinical development for mantle cell lymphoma (MCL). MCL is a rare type of non-Hodgkin lymphoma (NHL) that usually behaves like a fast-growing lymphoma. It develops when B-cells, white blood cells, become abnormal. The abnormal B-cells usually build up in lymph nodes, but they can affect other parts of the body. MCL often responds well to frontline chemotherapy but the responses are not durable and often of relatively short duration. Once MCL has entered the relapsed/refractory stage, it becomes more difficult to treat and patients deteriorate at an increasing pace.
Pirtobrutinib is expected to work by reversibly binding to a protein that is critical for the survival and growth of tumour cells; this will inhibit its action, killing tumour cells. Previous inhibitors have been particularly efficacious but due to permanent binding, resistance and intolerance have occurred, so their use must be stopped. In contrast, pirtobrutinib reversibly binds which suggests intolerance and resistance are less likely. If licensed, pirtobrutinib, given orally, will offer an additional second-line or greater treatment for patients with relapsed or refractory MCL who have received prior Bruton’s tyrosine kinase (BTK) treatment.

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