Pancreatic cancer is caused by the abnormal and uncontrolled growth of cells in the pancreas – a large gland that is a part of the digestive system. Locally advanced pancreatic cancer (LAPC) means the cancer has spread into nearby large blood vessels and possibly the lymph nodes. It may have spread into the stomach, bile duct or small bowel, but not to organs further away in the body. More than three quarters of patients with pancreatic cancer have locally advanced or metastatic disease at the time of diagnosis, and are not candidates for surgical curative intervention. The cause of pancreatic cancer is not fully understood but several risk factors have been identified, one of which is a mutation in KRAS genes.
siG12D‐LODER is a gene therapy currently being developed for the treatment of LAPC. It is a small biodegradable material containing the active component of the drug (siG12D) and is injected directly into the tumour. siG12D‐LODER acts by inhibiting the KRAS genes and therefore reducing tumour growth in the pancreas. If licensed, siG12D‐LODER in addition to standard chemotherapy will offer an additional treatment option for patients with locally advanced pancreatic cancer.
Ixazomib citrate is a novel oral medicinal product that is already licensed in the UK for the treatment of MM in patients who have received at least one prior therapy (in combination with lenalidomide and dexamethasone). Ixazomib citrate offers the potential advantage over similar medicines in its class of being more effective in its anticancer activity, less toxic (reduced side effects) and more convenient to administer (through its weekly oral dosing). If approved as maintenance therapy following stem cell transplant in newly diagnosed MM patients, ixazomib citrate has the potential to improve the success rates of treatment by improving progression free survival and overall survival as well as presenting a more convenient way of administration that allows long term administration and improvement of patients’ quality of life.