Tendoncel is a gel which can be applied directly onto the skin of the elbow. Tendoncel gel contains a mixture of growth factors (a small substance which encourages cells to grow) which help the tendon to repair and heal. A clinical trial of tendoncel in people with severe tennis elbow showed improvements in elbow pain.If tendoncel was licensed in the UK, it would provide a less invasive treatment option to people with severe or prolonged tennis elbow which may delay the need for surgery and improve symptoms.
Palovarotene is in clinical development for episodic use in the prevention of heterotopic ossification (HO) in patients with fibrodysplasia ossificans progressiva (FOP). FOP is a disabling condition, caused by the formation of bony bars within the muscles of the body (HO). This bone formation is usually first noticed in early childhood as a series of hard lumps in the neck or along the spine. These lumps, which may be tender, gradually shrink in size as the affected muscles are replaced by bone. The appearance of bony lumps in muscles is usually spontaneous but can also be provoked by any injury to the muscles.