Tofacitinib is in development for the treatment of polyarticular juvenile idiopathic arthritis (JIA). JIA is defined as arthritis of unknown aetiology that manifests itself before the age of 16 years and persists for at least 6 weeks, while excluding other known conditions. Polyarticular JIA, a subgroup of JIA is characterised by the involvement of five or more joints during the first 6 months of the disease and can be considered rheumatoid factor positive or negative. The most common symptoms include joint swelling, pain and limited range of motion. Currently available treatment of JIA aims to control symptoms, reduce the possibility of joint damage and improve quality of life.
Tofacitinib works by blocking the action of enzymes known as Janus kinases. These enzymes play an important role in the inflammatory process. By blocking the enzymes’ action, tofacitinib helps reduce the inflammation and other symptoms of these diseases. Tofacitinib is an oral alternative to the available biological medicines for children with JIA, most of which are administered by injection. If licensed, tofacitinib may offer an additional treatment option for polyarticular JIA with the potential advantage of improving the quality of life of children due to its oral formulation.
NOVOCART 3D Autologous Chondrocyte Transplantation System is a biologic-device combination product composed of autologous (the patient’s own) chondrocytes (cartilage producing and maintaining cells) seeded on a bioresorbable three-dimensional collagen scaffold, which is secured directly into the defect. The use of NOVOCART 3D involves two separate surgeries. In the first surgery, a small amount of knee cartilage is removed from the patient’s affected knee and sent to the company to be processed for re-implantation. In a second surgery, the damaged area of the knee cartilage is cleaned and the sponge-like scaffold containing the autologous chondrocytes is implanted. If licensed, NOVOCART 3D will offer an additional treatment option for repair of articular cartilage defects of the knee.