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This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Cancer and Palliative Care

Results

Drugs

January 2020

Durvalumab for advanced, EGFR/ALK wild-type, high PD-L1 expression, non-small cell lung cancer- first line

Durvalumab is in development for patients with advanced/metastatic non-small cell lung cancer (NSCLC) who are EGFR/ALK wild-type and whose tumours have a high PD-L1 expression. NSCLC makes up the majority of lung cancers in the UK. Advanced/metastatic (Stage IV) NSCLC is when the cancer has spread beyond the lung which was initially affected, most often to the liver, the adrenal glands, the bones and the brain. Most patients with NSCLC are diagnosed at the advanced/metastatic stage where curative treatment with surgery is unsuitable. Currently, chemotherapy remains the first line treatment option but this is often not well tolerated by many patients.

Drugs

January 2020

Nivolumab in combination with chemotherapy for early-stage non-small cell lung cancer – neoadjuvant

Nivolumab in combination with chemotherapy is in clinical development as a neoadjuvant treatment for early-stage (stage IB-IIIA) operable non-small cell lung cancer (NSCLC). NSCLC is the most common type of lung cancer. Early-stage lung cancer is typically treated with surgery consisting of removing either part of or the whole of the lung, followed by chemotherapy and/or radiotherapy (adjuvant). However, the long-term outlook for patients undergoing this treatment pathway is still poor. Treatment with medicines prior to surgery (neoadjuvant) may provide better long-term survival prospects for patients with early-stage operable NSCLC.

Drugs

January 2020

Nivolumab in combination with ipilimumab for early stage non-small cell lung cancer -neoadjuvant

Nivolumab in combination with ipilimumab is in clinical development as a neoadjuvant treatment for early stage (stage IB-IIIA), resectable non-small cell lung cancer (NSCLC). NSCLC is the most common type of lung cancer. Early stage lung cancer is typically treated with surgery consisting of removing either part of the affected lung or the whole lung, followed by chemotherapy and/or radiotherapy. However, the long-term outlook for patients undergoing this treatment pathway is still poor. Neoadjuvant therapy, which is administered prior to surgery to reduce the tumour size, may provide better long-term survival prospects for patients with early-stage operable NSCLC.

Drugs

January 2020

Tepotinib for advanced non-small cell lung cancer harbouring MET exon14- skipping mutations

Tepotinib is in clinical development for patients with advanced non-small cell lung cancer (NSCLC) whose tumours have alterations in the MET gene. Advanced/metastatic (stage IV) NSCLC is when the cancer has spread to other organs most often to the liver, the adrenal glands, the bones and the brain. NSCLC is called locally advanced when it has spread into tissues around the lungs. Symptoms of NSCLC include fatigue, cough, shortness of breath, loss of appetite, coughing up phlegm, mucus or blood and chest pain. Most patients with metastatic NSCLC are diagnosed at the late stage where curative treatment with surgery is unsuitable. Currently, chemotherapy remains the main first line treatment option at this stage and is often not well tolerated by many patients.

Drugs

January 2020

Lenvatinib in addition to everolimus or pembrolizumab for advanced renal cell carcinoma – First line

The addition of lenvatinib to everolimus or pembrolizumab is in clinical development for the first line treatment of advanced renal cell carcinoma (RCC). RCC is the most common form of cancer that originates in the kidney. It may occur due to the mutation of cells in the kidney’s filtering system. RCC often has few symptoms, …

Drugs

December 2019

Selpercatinib for metastatic RET fusion-positive non-small cell lung cancer

Selpercatinib is in clinical development for the treatment of metastatic RET fusion-positive non-small cell lung cancer (NSCLC). NSCLC is the most common type of lung cancer and at the metastatic stage the disease has already spread from the lungs to other sites. Around 2% of these patients will have tumours that contain fusion mutations in the RET gene. Cells in these tumour produce altered RET signalling receptors that allow uncontrolled cancer growth. Currently the only treatment options that attempt to inhibit RET fusion-positive tumour activity are nonselective multikinase inhibitors.

Drugs

December 2019

Durvalumab for recurrent or metastatic squamous cell carcinoma of the head and neck – first line

Durvalumab is a medicinal product currently in development for the treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). SCCHN is a cancer that arises from cells called squamous cells. Squamous cells are found in the outer layer of skin and in the mucous membranes, the moist tissues that line body cavities such as the airways and intestines. SCCHN develops in the mouth, nose and throat. Recurrent or metastatic SCCHN typically exhibits poor patient outcomes, for which more effective therapies are required.

Drugs

December 2019

Durvalumab in addition to chemotherapy for metastatic non-small-cell lung cancer – first line

Durvalumab in addition to chemotherapy is in clinical development for stage 4 nonsmall cell lung cancer (NSCLC). NSCLC makes up the majority of lung cancers in the UK. Stage 4 (advanced/metastatic) NSCLC is when the cancer has spread beyond the lung which was initially affected, most often to the liver, the adrenal glands, the bones and the brain. Most …

Drugs

December 2019

Pembrolizumab in addition to trastuzumab and chemotherapy for HER2-positive advanced gastric or gastroesophageal junction adenocarcinoma – First-line

Pembrolizumab in addition to trastuzumab and chemotherapy is being developed for patients with HER2-positive advanced gastric or gastroesophageal junction adenocarcinoma. Gastric (stomach) cancer is cancer that starts anywhere inside the stomach or the stomach wall. Advanced gastric cancer means that a cancer that began in the stomach has spread to at least one other part of the body, such as the liver or lungs. HER2-positive means the cancer cells have too much HER2 protein on the surface of their cells, which can help cancer cells to grow. Advanced or metastatic cancer cannot usually be cured and current treatment aim to control the disease, relieve symptoms, and give patients a better quality of life. Trastuzumab combined with chemotherapy is a current treatment option.

Drugs

December 2019

Selpercatinib for advanced thyroid cancer with RET alterations

Selpercatinib is a first-in-class oral precision cancer medicine designed to selectively bind to cancers that harbour genetic abnormalities in the RET proteins. This binding inhibits the RET receptor signalling which in turn inhibits the tumour cell growth and may also prevent resistance to the treatment from developing. Selpercatinib is being developed for various RET-altered advanced thyroid cancers with early results indicating significantly improved outcomes. If licensed, selpercatinib will offer a treatment option for patients with advanced RET-mutant MTC and advanced RET fusion-positive thyroid cancer who have progressed following prior treatment and have no acceptable alternative treatment options.

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