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This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Ear, Nose and Throat

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Drugs

June 2019

Benralizumab in addition to mometasone furoate for severe nasal polyposis

Benralizumab in addition to mometasone furoate is in development for the treatment of severe nasal polyposis/polyps. Nasal polyps are painless soft growths inside the nose. The exact cause is still unknown but asthma and a bad reaction to aspirin are known to increase the risk of developing the disease. Nasal polyps contain inflammatory fluid and …

Drugs

May 2019

Omalizumab for chronic rhinosinusitis with nasal polyps

Omalizumab is a monoclonal antibody that targets and blocks the immunoglobulin E (IgE). Human IgE is produced in large quantities in patients with allergies and triggers an allergic reaction in response to an allergen. By attaching to IgE, omalizumab ‘mops up’ the free IgE circulating in the blood. This means that when the body encounters an allergen, there is less IgE available to trigger an allergic reaction. This helps to reduce the symptoms of CRSwNP. If licensed, omalizumab will offer a treatment option as add-on therapy for patients with CRSwNP who have had an inadequate response to current standard-of-care treatments.

Drugs

February 2019

Pioglitazone for sudden sensorineural hearing loss

Pioglitazone given both as an injection (directly into the inner ear) and oral tablets is being investigated as a treatment option for sudden sensorineural hearing loss (SSNHL) in adults. SSNHL, also known as sudden deafness, is an unexplained loss of hearing, typically in one ear and can happen instantly or over a span of several days. During this time, sound gradually becomes muffled or faint. SSNHL happens when organs in the inner ear or the nerve pathways between the ear and the brain become damaged. Whilst no medicines are authorised to treat the hearing loss itself, steroids are used to treat the symptoms or antibiotics if the cause is infection. Cochlear implants can be used but this does not completely restore hearing but amplifies sounds to a more normal level.

Reviews

March 2017

SUMMARY – New and emerging technologies for hearing loss

The NIHR Horizon Scanning Research and Intelligence Centre has published a horizon scanning review of new and emerging technologies that are being developed for the management and reduction of the negative consequences of hearing loss. More than 11 million, (approximately one in six) people in the UK are affected by hearing loss, the majority (92%) …

Reviews

March 2017

REVIEW – New and emerging technologies for hearing loss

The NIHR Horizon Scanning Research and Intelligence Centre has published a horizon scanning review of new and emerging technologies that are being developed for the management and reduction of the negative consequences of hearing loss. More than 11 million, (approximately one in six) people in the UK are affected by hearing loss, the majority (92%) …

Devices

June 2016

Chordate System S100 for chronic non-allergic rhinitis

The Chordate System S100 is a device to treat non-allergic rhinitis that is usually caused by infections or changes in the environment. Rhinitis occurs when the lining of nose becomes swollen and inflamed, usually because of swollen blood vessels and fluid build-up in the tissues of the nose. The device uses vibrations inside the nose …

Drugs

March 2016

AM-111 for acute sensorineural hearing loss – first line

Sensorineural hearing loss is caused by damage to the sensitive hair cells inside the inner ear or damage to the auditory nerve. This occurs naturally with age, as a result of injury (such as loud noises or middle/inner ear surgery), or due to unknown causes. Most cases of sudden sensorineural hearing loss are one-sided and …

Devices

October 2015

Serenity System® to treat tinnitus

Serenity® is designed to treat tinnitus, which is a noise or ringing in the ears. Currently, there is no treatment that works for everyone. Serenity® involves having a small implant placed in the patient’s chest. For short periods, this implant stimulates a nerve in the neck, at the same time as the patient is listening …

Devices

March 2015

AventaMed device for tympanostomy tube placement

The AventaMed device has been developed by AventaMed Ltd to perform tympanostomy tube surgery in children and adults with otitis media with effusion, Eustachian tube dysfunction and barotrauma. A tympanostomy tube (also known as a grommet or myringotomy tube) is a small drainage tube inserted into a small incision in the ear drum to relieve …

Diagnostics

October 2013

Lymphoseek® for lymphatic mapping and sentinel lymph node location in breast cancer, head and neck cancer and melanoma

Lymphoseek®, also known as Technetium Tc 99m Tilmanocept, is an injectable radio-labelled tracer that has been designed for lymphatic mapping and sentinel lymph node location in breast cancer, head and neck cancer and melanoma. It has been developed by Navidea™ Biopharmaceuticals.

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