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This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Endocrine, Nutritional and Metabolic

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Drugs

May 2019

Inclisiran for primary hypercholesterolaemia and mixed dyslipidaemia

The current standard of care for patients with hypercholesterolaemia is primarily statins which are capable of reducing LDL‐C. There is however a subset of patients who are unable
to reach LDL‐C goals despite maximally tolerated oral lipid lowering therapy. Inclisiran is a medicinal product that inhibits a protein called PCSK9 especially present on the liver cells
leading to a decrease in circulating LDL‐C. If licensed, inclisiran will offer an additional treatment option for patients with primary hypercholesterolaemia as adjunctive therapy to diet and in combination with other lipid‐lowering therapies.

Drugs

May 2019

Canagliflozin for chronic kidney disease in adult patients with type 2 diabetes mellitus

Canagliflozin belongs to a class of antidiabetic drugs called SGLT2 inhibitors that act by encouraging the body to filter out more glucose from the blood and excrete it via the urine. Canagliflozin is already licensed for use in type 2 diabetes mellitus but emerging evidence has also suggested that it offers substantial kidney protection, by slowing the progression of diabetic kidney disease. Canagliflozin will offer patients with type 2 diabetes mellitus who have chronic kidney disease a single treatment option to improve both kidney function alongside blood glucose control.

Drugs

April 2019

Liraglutide for weight management in obese adolescents aged 12-17 years old

Liraglutide acts like a hormone the body produces naturally that regulates appetite, known as glucagon-like-peptide (GLP-1). By activating areas of the brain that regulate appetite, liraglutide may decrease feelings of hunger which can lead to lower calorie intake and weight loss. If licensed, liraglutide may improve long-term outcomes for weight management in obese adolescents 12-17 years old who currently have limited treatment options.

Drugs

April 2019

Sotagliflozin for type 2 diabetes mellitus

Sotagliflozin is one of a new class of drugs that increase elimination of glucose in the urine. They offer the advantages of a reduced risk of low blood sugar. Sotagliflozin reduces the reabsorption of glucose from the intestines and kidneys, thus improving blood glucose control in diabetes mellitus. If licensed, sotagliflozin will offer an additional treatment option for patients with T2DM.

Drugs

February 2019

LY-900014 (ultra-rapid lispro) for adults with type 1 diabetes mellitus

LY-900014 (ultra-rapid lispro) is in development for the treatment of adult patients with type 1 diabetes mellitus. Type 1 diabetes mellitus is a condition which usually starts early in life and occurs as a result of the pancreas not producing enough (or sometimes any) insulin. This results in elevated blood sugar levels which can damage many organs in the body. Type 1 diabetes usually runs in families. While type 1 diabetes cannot be cured, having regular, at least daily, injections of insulin can keep blood sugar levels stable. However some people, despite having regular injections of insulin, still do not have stable blood sugar levels.

Drugs

October 2018

Apabetalone in addition to high-intensity statin therapy for preventing major adverse cardiac events in high-risk cardiovascular disease patients with type 2 diabetes mellitus

Apabetalone is the first product developed to inhibit BET proteins. These BET proteins can control the activity of cells and make them produce proteins that cause inflammation. By inhibiting the BET proteins the production of inflammatory proteins is reduced. Apabetalone also increases production of high density lipoproteins which removes excess cholesterol, reducing the risk of cardiovascular disease. Apabetalone has the potential to affect multiple processes which contribute to cardiovascular disease, with the overall result of reducing the risk of a major adverse cardiac event in diabetic patients. If licensed, apabetalone may offer an additional preventive treatment option for major adverse cardiac events in patients with type 2 diabetes mellitus, high-risk a high risk of cardiovascular disease and low HDL.

Drugs

August 2018

Oral Semaglutide for the treatment of type 2 diabetes mellitus

Semaglutide works by increasing the amount of insulin released from the pancreas and by delaying how quickly food moves through your digestive system, which aid in controlling blood sugar levels. Semaglutide belongs to a class of antidiabetic medications called glucagon-like peptide 1 (GLP-1) receptor agonist. Most other medications in this class are administered by injection under the skin. If licensed, semaglutide will be the first effective oral GLP-1 analogue for the treatment of type 2 diabetes and may improve acceptance and adherence for some patients compared with the injectable formulation of GLP-1 receptor agonists.

Drugs

May 2018

CER-001 for Familial Primary Hypoalphalipoproteinemia

CER-001 is an engineered complex of the major structural protein of HDL, in combination with key phospholipids. Administered through intravenous (IV) infusion, CER-001 mimics the structure and function of natural HDL to stimulate the removal of excess cholesterol and other lipids. There is currently limited treatment options available specifically for FPHA. If licensed, CER-001 may offer a new treatment option for FPHA by aiding in the transport and elimination of excess cholesterol and other lipids in the liver.

Drugs

April 2018

Sodium thiosulfate for acute calciphylaxis-associated pain in chronic haemodialysis patients

Sodium thiosulfate is an injectable solution that is being developed to treat calciphylaxis-associated pain in patients undergoing dialysis. It is thought that sodium thiosulfate works by attaching itself to the calcium to form a compound that is removed from the body in the urine, reducing the build-up of calcium in the arteries. If licensed, this product will provide a treatment option for patients with calciphylaxis, who currently have few effective treatments available.

Drugs

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