Ranibizumab for proliferative and non-proliferative diabetic retinopathy
Ranibizumab as intravitreal injections is in clinical development for the treatment of diabetic retinopathy in both its proliferative and non-proliferative forms. Diabetic retinopathy, is a disease that affect the retinas and other parts of the inner eye. It is a chronic progressive condition of the retinal blood vessels due to prolonged raised blood glucose. When new blood vessels and scar tissue form on the retina causing bleeding within the eye and loss of vision, it is called proliferative diabetic retinopathy.
Abicipar pegol for wet age related macular degeneration
Abicipar pegol is a novel therapeutic approach that uses a new generation of genetically engineered proteins that exhibit highly specific and high‐affinity target protein binding. As
an anti‐VEGF‐A, it works by inhibiting the growth of immature blood vessels that grow in the retina, reducing the haemorrhaging and scarring that leads to vision impairment. Abicipar
pegol has the potential to require less frequent injections into the eye than the current standard of care, while providing equal improvements in vision. If licensed this could be an effective treatment option with greater compliance for patients with wet age‐related macular degeneration.
ISV-305 for Ocular Inflammation and Pain Following Cataract Surgery
A cataract is any opacity of the lens, whether it is a small local opacity or a diffuse general loss of transparency. Sometimes, it can cause a significant reduction in visual acuity or a functional impairment. Cataract is the leading cause of blindness in the world. Cataract surgery is currently the only effective treatment to …
Ranibizumab for Retinopathy of Prematurity – first line
Ranibizumab is a medicinal product already available for treating a range of visual impairments in adult patients. It is injected directly into the eye and it works by preventing abnormal blood vessels from developing and growing in the eye (one of the causes of ROP) by blocking a protein called VEGF. If ranibizumab is licenced for treatment of ROP, it will be the first anti-VEGF medication to be approved for the treatment of ROP. This will potentially provide an alternative treatment to laser and surgical treatments for ROP.
Netarsudil plus latanoprost (Roclatan) for glaucoma or ocular hypertension
Glaucoma describes a group of disorders characterised by sight loss. Glaucoma is generally associated with high pressure in the liquids inside the eye but it can happen when the pressure level is normal. Individuals with consistently high eye pressure are at risk of developing glaucoma. Glaucoma does not normally cause any symptoms but once eye …
XG 102 for post-operative inflammation and pain following cataract surgery
XG 102 is a new drug injected into the eye to treat pain and inflammation in people who have had a cataract operation. A cataract occurs when the lens in the eye becomes cloudy causing blurred vision. Cataracts are very common and usually affect those over the age of 65 years. More than 300,000 cataract …
SUMMARY – New and emerging health technologies for corneal disorders
The NIHR Horizon Scanning Research and Intelligence Centre (HSRIC) has completed a horizon scanning review that identifies new and emerging technologies and procedures for the treatment of corneal disorders. This work was undertaken in response to a question raised by the James Lind Alliance Priority Setting Partnership on Sight Loss and Vision. Corneal disorders may …