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This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Neurology and Neurosurgery

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Drugs

June 2020

Abilify MyCite (aripiprazole with sensor) for bipolar disorder and schizophrenia

Abilify MyCite is a drug-device combination comprising aripiprazole embedded with an Ingestible Event Marker (IEM) sensor. The aripiprazole attaches in the brain to receptors which help normalise the activity of the brain. The drug is packaged within an innovative system which helps patients (and healthcare workers) monitor when the medication is taken through integration with a sensor patch and app. Abilify MyCite is different to other ways of monitoring whether medication has been taken because it gives results of the actual medication taken, without need for blood or urine samples, as opposed to an estimate and if licensed, will offer an additional treatment option for patients with BP1 and SCH.

Drugs

April 2020

Eptinezumab for prevention of Migraine

Eptinezumab is a drug, which potentially reduces the occurrence of migraine by blocking the CGRP ligand (a protein) from attaching to, and activating its receptor; a process thought to be involved in migraine. In clinical trials, eptinezumab appears effective and well tolerated in the prevention of migraine. If licenced, eptinezumab will offer an additional option for the preventative treatment of migraine with or without aura in adults.

Drugs

March 2020

Aducanumab for mild cognitive impairment due to Alzheimer’s disease

Aducanumab is a highly selective human antibody that specifically targets the β-amyloid (Aβ) protein which builds up in abnormal levels in the brain of people with Alzheimer’s disease. High levels of Aβ result in the protein clumping together to form plaques which disrupt neurone function. Aducanumab is given through intravenous infusion and if licensed, would offer an additional treatment option for Alzheimer’s disease and the first to treat the underlying disease rather than the symptoms.

Drugs

February 2020

Tofersen for the treatment of amyotrophic lateral sclerosis caused by mutations in the SOD1 gene

Tofersen (BIIB067) is in clinical development for the treatment of amyotrophic lateral sclerosis (ALS – also known as motor neurone disease) caused by mutations in the SOD1 gene (SOD1-ALS). ALS is a progressive disease of the nervous system, where nerve cells in the brain and spinal cord that control voluntary movement gradually deteriorate, causing loss of muscle function and paralysis. ALS is a debilitating and life-threatening disease. The gradual loss of neurons leads to a paralysing effect on muscles used for breathing, which usually leads to death from respiratory failure.

Drugs

February 2020

Daridorexant for Insomnia

Daridorexant is a medicinal product in clinical development for the treatment of adults with insomnia. Insomnia means regularly having problems sleeping, which results in impaired daytime functioning. Insomnia can be categorised according to its duration, into short-term insomnia (lasting less than 4 weeks) and long-term (or persistent) insomnia (lasting 4 weeks or longer).

Drugs

January 2020

Lasmiditan for acute treatment of migraine

Lasmiditan is a medicinal product currently in clinical development for the acute treatment of migraine. A migraine is usually a moderate or severe headache felt as a throbbing pain on one side of the head. Many people also have symptoms such as nausea, vomiting and increased sensitivity to light or sound. Migraines may be with aura (specific warning signs just before the migraine begins, such as seeing flashing lights), although the most common type is without aura (no specific warning signs).

Drugs

January 2020

Remimazolam for procedural sedation

Remimazolam has completed its main clinical development studies for procedural sedation in adults. Procedural sedation is a technique of administering sedatives or dissociative agents, with or without analgesics, to induce a mental state that allows the patient to tolerate unpleasant diagnostic and therapeutic procedures such as colonoscopy while maintaining cardiorespiratory function. This enables medical procedures to be carried out with the patient benefit of markedly reduced discomfort and no major added risk.

Drugs

July 2019

Lacosamide for primary generalised tonic-clonic seizures – adjunctive therapy

Lacosamide is a medicinal product that is being developed for the treatment of Primary Generalised Tonic-Clonic Seizures (PGTCS). Epilepsy is a neurological disorder that is characterised by an imbalance in the excitation and inhibition of the brain and this imbalance causes a phenomenon known as a seizure. Seizures are brief increases in electrical activity within …

Drugs

July 2019

Ofatumumab for relapsing multiple sclerosis

Ofatumumab is in clinical development for the treatment of relapsing multiple sclerosis (MS). Multiple sclerosis is an autoimmune disease, meaning the body’s own immune cells (which usually fight infection) attack and damage the nerves and brain. This causes a range of issues including problems with walking, balance, memory and thinking as well as pain, tiredness and many other symptoms.

Drugs

May 2019

Fenfluramine hydrochloride for treatment of seizures associated with Lennox-Gastaut syndrome

Fenfluramine belongs to a class of drugs called the selective serotonin releasing agonists which stimulates multiple 5-HT receptor sub-types through the release of serotonin. Fenfluramine may also act on other receptors and these actions may help to reduce the frequency of seizures. When added to other standard anti-epileptic treatments, fenfluramine hydrochloride has shown preliminary evidence of reducing seizure frequency. If licensed, fenfluramine hydrochloride may offer an additional treatment option for patients with Lennox-Gastaut syndrome.

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