Asciminib is in clinical development as a third line therapy for adult patients with chronic phase chronic myeloid leukaemia (CML) who have been previously treated with two or more tyrosine kinase inhibitors (TKI). CML is a slowly developing cancer that arises due to the production of abnormal immune cells known as white blood cells. In […]
Age-related macular degeneration (AMD) is a major cause of visual impairment in older adults in the UK. It has three stages - early, intermediate, and late - and can occur in one or both eyes. It is possible for one eye to be at the early stage and the other at late stage. There are […]
Alpelisib is a new drug that is being developed for patients with the HR+/HER2- type of advanced breast cancer. The drug is being developed to be given in combination with fulvestrant, a drug that is already in use for the treatment of advanced breast cancer. Alpelisib targets a very specific enzyme that transmits signals to […]
AMG 510 is in clinical development for the treatment of adults with KRASG12C mutated, metastatic non-small cell lung cancer (NSCLC). NSCLC is the most common form of lung cancer and a small proportion of patients with NSCLC have tumours which carry the genetic mutation KRASG12C. Metastatic NSCLC describes tumours that have spread from the lungs […]
Amivantamab is in clinical development in the treatment of patients with advanced non-small-cell lung cancer (NSCLC) who have previously been treated with platnum-based chemotherapy. NSCLC makes up the majority of lung cancers in the UK. Metastatic NSCLC is when the cancer has spread beyond the lung that was initially affected, most often to the liver, […]
Anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumour (IMT) are both rare conditions that usually affect children and young adults. ALCL is a type of cancer that occurs when T-cells, which contribute to the body’s immune system, become abnormal. IMTs are most commonly non-cancerous (benign), however in some cases the tumour can become cancerous […]
Angioedema is a rare blood disorder characterised by rapid swelling below the skin. Most often affect are hands, feet, eyes, lips or genitals. The swelling is caused by a collection of fluid in the deep layers of the skin. Hereditary Angioedema (HAE) is a rare condition caused by mutations that reduce the production or expression […]
Angiotensin II acetate is in clinical development for the treatment of catecholamine and/or vasopressin resistant hypotension due to distributive shock. Shock is a critical condition in which blood pressure drops so low that the brain, kidneys and other vital organs cannot receive enough blood flow to function properly. Distributive shock is the most common type […]
Anifrolumab is currently in clinical development for the treatment of moderately to severely active, autoantibody-positive systemic lupus erythematosus (SLE). SLE is an autoimmune disease where the body’s immune system attacks its own tissues and organs. Patients will often have periods where their symptoms flare-up and periods where their symptoms settle down. The exact causes of […]
ADV7103 is a combination product of potassium bicarbonate + potassium citrate extended release (i.e. the drug is released slowly over time). It is intended to treat distal renal tubular acidosis (dRTA) in adults, adolescents and children aged 6 months and older. DRTA disease occurs when the kidneys do not properly remove acids from the blood […]
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