Burosumab is in clinical development for the treatment of adults with tumour-induced osteomalacia (TIO). TIO is a rare disease where an overproduction of FGF23 leads to renal phosphate wasting and low levels of phosphate and vitamin D in the body. This causes weakening (or softening) of bones. Main symptoms include bone pain, muscle weakness/fatigue and […]
Burosumab is in clinical development for the treatment of adults with X-linked hypophosphataemia (XLH), and is currently licenced in children. XLH is an inherited disorder characterized by low levels of phosphate in the blood. Phosphate levels are low because phosphate is abnormally processed in the kidneys due to high levels of a protein called FGF23, […]
BV-NSCLC-002 is a new vaccine being develop to treat patients with advanced non-small cell lung cancer where the cells have a specific mutation (referred to as EGFR positive). The treatment is given as an injection at four sites after first-line chemotherapy then a reduced dose is given at two sites during the pre-progression phase.A study […]
Cabotegravir and rilpivirine long acting injections are in development for the treatment of HIV-1 patients that are considered clinically suitable for injectable therapy. HIV (Human Immunodeficiency Virus) is a type of viral infection caused by a virus referred as retrovirus. HIV-1 is the most common and highly communicable type of HIV. HIV is a lifelong, […]
Cabotegravir and rilpivirine tablets are in development as an oral lead-in therapy for a period of approximately one month as a short-term oral bridging treatment for Human Immunodeficiency Virus 1 (HIV-1) patients that are considered eligible for the long-acting injectable cabotegravir and rilpivirine therapy. HIV is a type of viral infection caused by a type […]
Brentuximab vedotin in addition to cyclophosphamide, doxorubicin, prednisolone (CHP) as intravenous infusion is in development for the treatment of CD30+ mature T-cell lymphoma also known as peripheral T cell lymphoma (PTCL), a subtype of non-Hodgkins lymphoma. PTCL is a group of aggressive and fast growing lymphomas that develop from mature white blood cells called T-cells […]
Brexanolone as an injection for intravenous infusion is in clinical development for women with moderate and severe postpartum depression (PPD). PPD is a mood disorder that can affect women after childbirth. Women with PPD experience feelings of extreme sadness, anxiety, and exhaustion that may make it difficult for them to complete daily care activities for […]
Brigatinib is a medicinal product that is being developed for the treatment of patients with locally advanced or metastatic ALK-positive non-small cell lung cancer (NSCLC) whose disease have progressed following treatment with alectinib or ceritinib. NSCLC is the most common type of lung cancer although a small proportion of NSCLC patients have a rearrangement in […]
Brolucizumab is in clinical development for the treatment of visual impairment due to diabetic macular oedema (DMO). DMO is a condition affecting the retina, the nerve layer at the back of the eye. The central part of the retina known as the macula, is responsible for fine detail vision, both for near (reading) and for […]
Budesonide 9mg gastro-resistant granules are in clinical development for the induction of remission in patients with lymphocytic colitis. Lymphocytic colitis is an inflammatory bowel disease that causes bouts of severe diarrhoea. Certain medications, viruses and bacteria can trigger lymphocytic colitis, however the cause of the disease is not known; it is thought that genetic and […]
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