Nivolumab in combination with ipilimumab in addition to standard of care chemotherapy is in clinical development for the treatment of metastatic (stage 4) non-small cell lung cancer (NSCLC). NSCLC accounts for the majority of lung cancer cases. The main symptoms of NSCLC include persistent cough, shortness of breath and coughing up blood. Factors increasing the […]
Nivolumab in addition to temozolomide and radiotherapy is being investigated as a treatment option for adult patients newly diagnosed with MGMT-methylated glioblastoma. Glioblastoma is a fast‐growing type of brain tumour and the MGMT-methylated status can help to predict how some patients might respond to treatment. MGMT-methylated glioblastoma is an aggressive brain cancer that typically results […]
Niraparib as an oral formulation is in clinical development for maintenance therapy in patients with advanced ovarian, fallopian tube or primary peritoneal cancer following response to first-line platinum-based chemotherapy. Ovarian cancer includes a group of tumours that arise from diverse types of tissue contained in the ovary. The most common type of ovarian cancer arises […]
Nitisinone is in clinical development for the treatment of alkaptonuria. Alkaptonuria is a rare metabolic disorder, in which patients lack a functional enzyme that prevents the body fully breaking down two amino acids called tyrosine and phenylalanine. This results in a build-up of a chemical called homogentisic acid (HGA) in the body, which is deposited […]
Nivolumab and ipilimumab is a combination therapy to treat cancer of the large bowel (colon) or back passage (rectum) – these types of cancers (bowel and colon) are also known as colorectal cancer. Metastatic colorectal cancer occurs when the cancer has spread to another part of the body; this is most commonly to the liver. […]
Nivolumab in addition to radiation therapy is being investigated as a treatment option for patients newly diagnosed with glioblastoma. Glioblastoma is a fast‐growing type of brain tumour that develops from glial cells in the brain. It is an aggressive brain cancer that typically results in death within months following diagnosis if not treated. Brain cancers […]
Niraparib is in clinical development for the treatment of metastatic castrate-resistant prostate cancer (mCRPC) with DNA-repair anomalies. Prostate cancer is the most common type of cancer in men in the UK. The cancer is called advanced (metastatic) prostate cancer when the cancer cells have spread to other parts of the body like bones, lymph nodes […]
Nintedanib is an oral medicinal product under clinical development for patients with progressive fibrosing interstitial lung disease (PF-ILD). ILDs belong to a group of over 200 rare conditions that affect the tissue and space around the air sacs of the lungs, where tissue becomes thickened, stiff and scarred over a period of time. PF-ILDs are […]
Neuromyelitis optica (Devic’s disease) is a rare autoimmune disorder (a condition where the immune system attacks itself). It is characterised by the inflammation of the nerve that leads from the eye to the brain, and the spinal cord. Symptoms consist of vision loss, loss of sensation, bladder dysfunction, weakness in limbs and paralysis and most […]
Nerinetide is in clinical development for the treatment of acute ischaemic stroke. Ischaemic stroke is the most common type of stroke. It happens when a blood vessel is blocked by a blood clot, cutting off blood flow to part of the brain (ischaemia). Without blood supply, brain cells can be damaged or destroyed because they […]
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