Malignant pleural mesothelioma is a type of cancer of the lungs caused mostly by exposure to asbestos. When asbestos fibres are inhaled, they can cause tumours to grow in the pleura, the thin membrane of cells (mesothelium) that line the lungs and chest wall. The disease is five times more common in men than women, […]
Lorlatinib is being investigated for the treatment of advanced anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC). NSCLC comprises the majority of lung cancers in the UK. Symptoms of lung cancer include a persistent cough, shortness of breath, coughing up blood, aches and pains in the chest or shoulder, loss of appetite, weight […]
Lumasiran is in clinical development for the treatment of primary hyperoxaluria type I (PH1) in paediatric patients up to 5 years old. PH1 is a very rare disease caused by certain genetic mutations, in which excess production of a substance called oxalate results in the deposition of oxalate crystals in the kidneys and urinary tract. […]
Lumasiran is in clinical development for the treatment of primary hyperoxaluria type I (PH1). PH1 is a very rare disease caused by certain genetic mutations, in which excess oxalate production results in the deposition of oxalate crystals in the kidneys and urinary tract. This leads to stone formation and kidney failure with significant morbidity and […]
Lumateperone is a new, orally administered antipsychotic drug which alters levels of several chemicals in the brain including dopamine, serotonin and glutamate. Studies on lumateperone in people with schizophrenia experiencing an episode of severe symptoms suggest it may reduce symptoms with less side effects than current antipsychotic medication.If licensed lumateperone may provide an alternative treatment […]
Lung cancer is the second most common type of cancer. The most common type of lung cancer is nonsmall cell lung cancer (NSCLC). NSCLC has three sub-types that can be further grouped by their specific genetic mutation. Two of these types are ALK-positive and ROS1-positive lung cancer, both of which fuse with other genes and […]
Lurbinectedin in addition to doxorubicin is in clinical development for the treatment of adults with small-cell lung cancer (SCLC) who have progressed after prior platinum-containing therapy. SCLC is an aggressive type of lung cancer that is associated with smoking. The condition is often diagnosed at a late stage, when the cancer has spread to other […]
Lung cancer arises from cells in the lungs that have grown abnormally and multiplied to form a tumour. Non-squamous non-small cell lung cancer (NSCLC) is a type of lung cancer that is differentiated from small-cell lung cancer (SCLC) by the way the tumour cells look under a microscope. Symptoms include a persistent cough, hoarseness, shortness […]
Loncastuximab tesirine is currently in clinical development for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL). DLBCL is a type of blood cancer that develops when white blood cells, called lymphocytes, grow out of control. The affected lymphocytes lose their infection fighting ability making the body more susceptible ot infection. Relapsed cancer […]
Lonafarnib is in clinical development for the treatment of Hutchinson-Gilford Progeria syndrome (HGPS) and other progeroid laminopathies (PL). Progeroid laminopathies are characterised by the premature appearance of certain signs of physiological ageing in a subset of tissues, and the most prevalent of these rare diseases is HGPS. HGPS is caused by genetic abnormalities in a […]
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