Epilepsy is a condition in which the brain is affected by abnormal discharge of electrical activity, causing seizures (fits). There are several different types of epileptic seizures, depending on what part of the brain they start in and which part they affect. Epilepsy can start in any age, but is most common in either childhood […]
Efgartigimod alfa is currently in clinical development for the treatment of adults with generalised myasthenia gravis (gMG). gMG is a long-term autoimmune disorder that leads to muscle weakness and tiredness, and which can be seriously debilitating and life-threatening. Currently there are no medicinal products recommended by NICE specifically for the treatment of gMG, and medicines […]
Eladocagene exuparvovec is in clinical development for the treatment of patients with deficiency of a protein called aromatic L-amino acid decarboxylase (AADC). AADC-deficiency is a very rare inherited disease which affects the way signals are passed between certain cells in the nervous system. AADC-deficiency is caused by changes or mutations in the dopa decarboxylase (DDC) […]
Elranatamab is in clinical development for relapsed/refractory multiple myeloma (MM). MM is a rare, incurable cancer of the blood that develops from plasma cells in the bone marrow (the spongy tissue inside the inner part of some bones) where large amounts of abnormal plasma cells are produced and interfere with the production of red and […]
Empagliflozin is currently in clinical development for the treatment of heart failure (HF) with reduced ejection fraction. HF is a complex clinical syndrome of symptoms and signs that suggest the efficiency of the heart to pump blood around the body is impaired. Symptoms of HF include breathlessness, fatigue and ankle swelling, and signs of the […]
Empagliflozin is in clinical development for chronic heart failure and preserved ejection fraction (HFpEF). Heart failure (HF) is a clinical syndrome caused by the impaired ability of the heart to cope with the metabolic needs of the body. This results in breathlessness, fatigue, and fluid retention. The European Society of Cardiology(ESC) defines HFpEF as the […]
Encorafenib in combination with binimetinib and cetuximab (triple therapy) is in clinical development for the treatment of patients with BRAF V600E mutant metastatic colorectal cancer (mCRC) whose disease has progressed after 1 or 2 prior regimens in the metastatic setting. Colorectal (or bowel) cancer starts in the large bowel (colon) and the back passage (rectum) […]
Enfortumab vedotin is currently in clinical development for the treatment of locally advanced or metastatic urothelial cancer in patients who have previously received chemotherapy and immunotherapy. Urothelial cancer, a subset of bladder cancer, occurs on the lining of the renal pelvis, ureter, bladder and urethra, and other parts of the urinary system. In advanced urothelial […]
Edasalonexent is currently in clinical development for the treatment of male paediatric patients with Duchenne muscular dystrophy (DMD). DMD is a rare genetic condition caused by a mistake or abnormality in a gene called dystrophin, located on the X chromosome (one of the two sex chromosomes). Chromosomes are tiny structures inside cells made from deoxyribonucleic […]
Edaravone as an intravenous injection is in clinical development for people with amyotrophic lateral sclerosis (ALS). ALS is a neurological condition that affects nerve cells in the brain and spinal cord. It results in gradual weakness and wasting of muscles of the body. Respiratory muscles are involved as the disease progresses, leading to shortness of […]
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