Inebilizumab is a humanised monoclonal antibody that is in clinical development for reducing the risk of an attack in patients with Neuromyelitis Optica Spectrum Disorders (NMOSD). NMOSD, previously known as NMO and as Devic's disease, is a rare, disabling autoimmune disease of the central nervous system. It predominantly affects the optic nerve and spinal cord, […]
Ibrutinib in combination with venetoclax is being developed for elderly and at risk patients with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). CLL and SLL are types of cancer in which too many white blood cells are produced, in SLL cells build up in the lymph nodes, in CLL the cancer cells can […]
Icosapent ethyl is in clinical development as a treatment to reduce the risk of cardiovascular events in high-risk patients who have their cholesterol levels controlled with statin treatment, but have elevated triglycerides and other cardiovascular risk factors. Cardiovascular events include heart attack, angina and stroke. These diseases are the main cause of death in the […]
Ibrutinib in addition to rituximab is being developed for young and fit untreated patients with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). CLL is a type of cancer in which too many white blood cells are produced. As these cells develop abnormally, they are unable to function, fight infection and reduce the production […]
Ibrutinib is a drug which blocks signals in cancer cells which helps the cancer cell survive and grow resulting in the cells death and preventing the cancer from growing. Early clinical trials of ibrutinib in follicular lymphoma (FL) patients suggest it may reduce symptoms and ongoing clinical trials will determine if ibrutinib will extend life […]
Ibrutinib is in clinical development for chronic graft versus host disease (cGvHD). After a donor stem cell transplant, the donor’s stem cells (the graft) may sometimes react against the host’s own cells. This is called Graft versus Host Disease (GvHD). cGvHD may happen more than three months after transplant. The symptoms depend on which parts […]
Idasanutlin in addition to cytarabine is in development for the treatment of relapse or refractory Acute Myeloid Leukaemia (AML). AML is a type of cancer that causes the bone marrow (the soft inner part of the bones where new blood cells are made) to produce excess immature white blood cells. The term acute means that […]
IgA nephropathy (IgAN) also known as Berger’s disease is one of the most common kidney diseases, aside from those caused by high blood pressure or diabetes. It is an autoimmune (where the immune cells attack the body) disease affecting the kidneys. IgA antibodies are molecules made by immune cells which help stop intruders from attacking […]
Hypersomnia means excessive sleepiness and sleeping, when the person struggles to stay awake during the day and has great difficulty being awakened from sleep. When there is no clear cause, this condition is called idiopathic hypersomnia (IH). Narcolepsy is a rare long-term brain disorder that causes a person to suddenly fall asleep at inappropriate times. […]
Ibalizumab in combination with other antiretroviral(s) has been developed for the treatment of adults infected with multidrug-resistant HIV-1 (MDR HIV-1). HIV is a virus that damages the cells in the immune system and weakens the ability to fight everyday infections and diseases. HIV-1 is the most common type of HIV infection, which is incurable but […]
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