This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Drugs > Tagraxofusp for blastic plasmacytoid dendritic cell neoplasm

< Back

Tagraxofusp for blastic plasmacytoid dendritic cell neoplasm


Cancer and Palliative Care

September 2018

Tagraxofusp is being investigated for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN). Previously known as natural killer (NK) cell leukaemia/lymphoma, BPDCN
was categorized by the World Health Organization under acute myeloid leukaemia (AML) but now has its own separate designation under myeloid neoplasms. BPDCN is a rare blood
cancer derived from the precursors of cells called plasmacytoid dendritic cells.
Tagraxofusp is a fusion protein formed by combining interleukin‐3 (IL‐3) and truncated diphtheria toxin (DT). It causes inactivation of protein synthesis, and death of the target cell.
Treatment for BPDCN has included therapies that are used for AML, acute lymphoblastic leukaemia (ALL), or lymphoma. If licensed, tagraxofusp will offer the first prospectively
studied treatment option for BPDCN for which there are limited treatment options and a significant unmet medical need.

Innovation Observatory Voice 0

Leave a Reply

Your email address will not be published. Required fields are marked *

Post Comment

Download Full Article


Connect to the Innovation Observatory


Load More Related Posts

Get Alerts