logo
Menu

This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Cancer and Palliative Care

Results

Drugs

September 2021

Ciltacabtagene autoleucel for relapsed and refractory multiple myeloma

Ciltacabtagene autoleucel is in clinical development for the treatment of adults with relapsed and lenalidomide-refractory multiple myeloma (MM). MM is a rare, incurable cancer of the plasma cells in the bone marrow. Abnormal plasma cells interfere with the production of red and white blood cells as well as platelets, causing symptoms such as bone pain …

Drugs

September 2021

Pembrolizumab in combination with olaparib for treatment of metastatic squamous non-small cell lung cancer

Pembrolizumab in combination with olaparib is in clinical development for the treatment of metastatic squamous non-small cell lung cancer (NSCLC). NSCLC makes up the majority of lung cancers in the UK and squamous NSCLC is where the cancer begins in the flat cells that cover the surface of the airway. Metastatic (advanced) NSCLC refers to …

Drugs

September 2021

Nivolumab in combination with chemoradiotherapy for squamous cell head and neck cancer

Nivolumab in combination with cisplatin-based chemoradiotherapy (cisplatin-RT) is currently in development for the adjuvant treatment of high-risk patients with metastatic squamous cell carcinoma of the head and neck (HNSCC) following surgery to remove the cancer. HNSCC is a cancer of the mouth, nose or throat that develops in the squamous cells found in the outer …

Drugs

September 2021

Talazoparib in addition to enzalutamide for metastatic castration-resistant prostate cancer

Talazoparib in addition to enzalutamide is in clinical development for patients with metastatic castration-resistant prostate cancer (mCRPC). Prostate cancer is the most common type of cancer in men in the UK. The cancer is called advanced (metastatic) prostate cancer when the cancer cells have spread to other parts of the body like bones, lymph nodes …

Drugs

August 2021

Sabatolimab in addition to azacitidine for myelodysplastic syndromes – first-line

Sabatolimab in addition to azacitidine is in clinical development for the treatment of higher risk myelodysplastic syndromes (MDS) in adults. Myelodysplastic syndromes are a group of cancers in which immature blood cells in the bone marrow do not mature or become healthy blood cells. MDS are long-term debilitating and life-threatening diseases Sabatolimab targets an inhibitory …

Drugs

August 2021

Pembrolizumab for Hepatocellular Carcinoma – Adjuvant

Pembrolizumab is in clinical development as an adjuvant treatment for hepatocellular carcinoma (HCC). HCC is the most common type of liver cancer. This type of cancer develops from the main liver cells, called hepatocytes. Treatment and survival depends on the stage at which the cancer is diagnosed. HCC is more common in people who have …

Drugs

August 2021

Pembrolizumab in combination with neoadjuvant chemotherapy and adjuvant endocrine therapy for early-strage breast cancer

Pembrolizumab in combination with neoadjuvant chemotherapy and adjuvant endocrine therapy is in clinical development for the treatment of early-stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) breast cancer. Early breast cancer is where the disease is limited to the breast region and has not spread to other parts of the body. Treatment of …

Drugs

August 2021

Infigratinib for unresectable locally advanced or metastatic cholangiocarinoma with FGFR2 rearrangements – second line

Cholangiocarcinoma (CCA) is a rare type of cancer that affects the bile ducts. Locally advanced CCA is when the cancer spreads from its original site to surround areas, but has not spread to other parts of the body. Metastatic CCA is when the cancer has spread to other areas of the body. Current treatment options …

Drugs

August 2021

Mobocertinib for locally advanced or metastatic NSCLC

Mobocertinib (TAK-788) as a monotherapy is in clinical developmentfor the treatment oflocallyadvanced or metastatic non-small cell lung cancer (NSCLC). NSCLC makes up the majority of lung cancers in the UK. In locally advanced or metastaticNSCLC(StageIIIB orIV),the cancer has spread beyond the lung which was initially affected. Symptoms of lung cancer include a persistent cough, shortness …

Drugs

August 2021

Amivantamab for advanced non-small-cell lung cancer

Amivantamab is in clinical development in the treatment of patients with advanced non-small-cell lung cancer (NSCLC) who have previously been treated with platnum-based chemotherapy. NSCLC makes up the majority of lung cancers in the UK. Metastatic NSCLC is when the cancer has spread beyond the lung that was initially affected, most often to the liver, …

Get Alerts