Search All Tech Briefings

Search technology briefings produced by NIHR Innovation Observatory. These are short reports on new or repurposed medicines that we have already sent to our stakeholders. Only those technologies (medicines) that are within the scope of our stakeholders will have a technology briefing available. Search our technology briefings by intervention (drug or device), specific indication (disease or condition), or general therapeutic area.

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Title	Intervention	Indication	Therapeutic Area	Year	Actions
Alpelisib in Combination with Fulvestrant for Advanced HR Positive, HER2-negative Breast Cancer in Men and Postmenopausal Women	Alpelisib (BYL719; Piqray) , Fulvestrant (Faslodex)	Breast cancer	Breast Cancer	2017	View \| Download
ALXN 1210 for Paroxysmal Nocturnal Haemoglobinuria – First Line	Ravulizumab (ALXN1210; Ultomiris)	Paroxysmal nocturnal haemoglobinuria (PNH)	Haematology	2017	View \| Download
AMG 510 for KRAS G12c mutated metastatic non-small cell lung cancer - after prior standard therapy	Sotorasib (AMG 510)	Non-small-cell lung cancer (NSCLC)	Lung and Respiratory Cancer	2020	View \| Download
Amivantamab for advanced non-small-cell lung cancer	Amivantamab (JNJ-6372; JNJ-61186372)	Non-small-cell lung cancer (NSCLC)	Lung and Respiratory Cancer	2021	View \| Download
Amivantamab with chemotherapy for previously untreated advanced EGFR exon 20 insertion mutations positive non-small cell lung cancer	Amivantamab (JNJ-6372; JNJ-61186372) , Chemotherapy	Non-small-cell lung cancer (NSCLC)	Lung and Respiratory Cancer	2022	View \| Download
Amivantamab with lazertinib for previously untreated locally advanced or metastatic non-small-cell lung cancer	Amivantamab (JNJ-6372; JNJ-61186372) , Lazertinib	Non-small-cell lung cancer (NSCLC)	Lung and Respiratory Cancer	2023	View \| Download
Anakinra for Still’s disease	Anakinra (Kineret)	Juvenile idiopathic arthritis	Rheumatology	2018	View \| Download
Angiotensin II acetate (Giapreza) for vasopressor resistant hypotension due to distributive shock	Angiotensin II acetate (Giapreza; LJPC-501)	Orthostatic hypotension	Cardiovascular System	2018	View \| Download
Anifrolumab for moderately to severly active, autoantibody-positive systemic lupus erythematosus	Anifrolumab (MEDI546)	Systemic lupus erythematosus (SLE)	Immunology , Nephrology	2020	View \| Download
Apabetalone in addition to high-intensity statin therapy for preventing major adverse cardiac events in high-risk cardiovascular disease patients with type 2 diabetes mellitus	Apabetalone (RVX-208)	Major adverse cardiovascular events (MACE)	Cardiovascular System , Endocrine Nutritional and Metabolic Disorders	2018	View \| Download