Cardiovascular disease (CVD) is a general term that refers to all conditions affecting the heart and blood vessels (circulation). These include angina, heart attack (also known as myocardial infarction), heart failure, stroke, and a number of diseases that affect the blood vessels.
CVD is usually associated with a build-up of fatty deposits inside the blood vessels (arteries) which make the vessels become narrowed (atherosclerosis). The body also reacts to the fatty deposits by sending white blood cells to the blood vessels; this process is called inflammation. The fatty deposits along with the inflammation lead to reduction of the blood supply to the heart and significantly increase the risks of heart attack and other types of cardiovascular diseases.
Canakinumab is a medicine being developed to target inflammation. It is the first and only agent which has shown that by selectively targeting some specific biomarkers of inflammation, it significantly reduces cardiovascular risks. Canakinumab is currently being developed to be used as an add-on therapy for patients who have had a prior heart attack and have a higher risk of further cardiovascular disease.
Angiotensin II acetate is in clinical development for the treatment of catecholamine and/or vasopressin resistant hypotension due to distributive shock. Shock is a critical condition in which blood pressure drops so low that the brain, kidneys and other vital organs cannot receive enough blood flow to function properly. Distributive shock is the most common type of shock that is most commonly caused by bacterial or fungal infection (septic shock) or allergic reaction (anaphylactic shock). Severe shock is usually treated with drugs called catecholamines or vasopressin. Shock that does not respond to treatment with these drugs is resistant shock.