Familial adenomatous polyposis (FAP) is rare condition that can often run in families, but it can also develop in people who do not have a family history of the condition. FAP causes hundreds or thousands of small growths called polyps to develop in the large bowel. These polyps are not cancerous, but if they are not treated some of them are likely to develop into cancer. If there is a family history of FAP, patients will have regular screening from a young age, usually done as a colonoscopy. Polyps usually appear when a person is in their teens if they have classical FAP, and around 10 years later if they have attenuated FAP. For patients with classical FAP, there is a nearly 100% risk of progression to colorectal cancer by 40 years of age if no treatment has been given. The only preventative treatment available for FAP is surgery to remove the colon and sometimes the rectum. After surgery, patients often need to go to the toilet more often, and may need to have a stoma (an opening in the abdomen allowing faeces to be collected in a bag).
Eflornithine in combination with sulindac is being developed as a treatment for FAP. Both these drugs slow down the growth of the polyps in different ways, and taking them together is thought to be potentially more effective than taking them alone. If licensed, this drug combination could reduce or delay the need for surgery or other major endoscopic procedures for people with FAP.
Ixazomib citrate is a novel oral medicinal product that is already licensed in the UK for the treatment of MM in patients who have received at least one prior therapy (in combination with lenalidomide and dexamethasone). Ixazomib citrate offers the potential advantage over similar medicines in its class of being more effective in its anticancer activity, less toxic (reduced side effects) and more convenient to administer (through its weekly oral dosing). If approved as maintenance therapy following stem cell transplant in newly diagnosed MM patients, ixazomib citrate has the potential to improve the success rates of treatment by improving progression free survival and overall survival as well as presenting a more convenient way of administration that allows long term administration and improvement of patients’ quality of life.