Filgotinib is in development for the treatment of adults with moderate to severe active rheumatoid arthritis (RA) as front-line therapy or for those which previous treatment with a disease-modifying anti-rheumatic drug (DMARD) has not worked or are unable to take it. RA is a long-term, autoimmune disease that causes pain, swelling and stiffness in the joints. The condition occurs in women more often than men. The symptoms usually affect the hands, feet and wrists. There may be periods where symptoms become worse, known as flare-ups. Some people with RA also experience problems in other parts of the body, or more general symptoms such as tiredness and weight loss.
Filgotinib is a new Janus Kinase (JAK) inhibitor. JAK pathways are involved in the inflammatory process in RA. Filgotinib is highly selective for JAK1. By blocking the JAK1 pathway, filgotinib may help ease the RA symptoms. Filgotinib can be taken orally as a tablet once a day and it has shown to be safe. Filgotinib may be taken as monotherapy or in combination with methotrexate or other non-biologic DMARDs. If approved for the treatment of moderate to severe RA, filgotinib will offer an additional front line or a later line treatment option for this population group.
Guselkumab is a type of biologic medicine that has been designed to suppress immune response associated with psoriasis. It works by specifically targeting a chemical messenger (known as a cytokine) in the body called interleukin-23 (IL-23). The IL-23 are produced by leucocytes (mainly by lymphocytes T, macrophages and eosinophils) in response to mechanical stress, and has an important role in the pathogenesis of psoriasis and psoriatic arthritis. Guselkumab is already licensed in the EU/UK for the treatment of moderate to severe plaque psoriasis and may offer an additional treatment option for patients with active psoriatic arthritis.