logo
Menu

This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Drugs > Imlifidase for kidney transplantation in highly sensitised patients with chronic kidney disease

< Back

Imlifidase for kidney transplantation in highly sensitised patients with chronic kidney disease

Drugs

Gastrointestinal, Pancreatic and Liver Disease

July 2019


Imlifidase is in clinical development for enabling kidney transplantation in highly sensitised patients with chronic kidney disease (CKD). CKD is a long-term irreversible condition where the kidneys do not work as well as they should. Kidney transplantation is considered to be treatment of choice for patients with end stage kidney disease. Many patients on the waiting list for organ transplantation carry antibodies to human leukocyte antigen (HLA), which is known as being ‘sensitised.’ Patients who are highly sensitised may find it difficult getting a donor and may not be able to receive a transplant due to increased risk of kidney rejection.
Imlifidase is made of an enzyme derived from the bacterium called Streptococcus pyogenes. It specifically cleaves all human subclasses of proteins called immunoglobulin IgG. This mechanism inhibits all IgG mediated immunity and prevents rejection of a transplanted kidney. If licensed, imlifidase will offer a treatment that enables kidney transplantation in highly sensitised patients with CKD.

Innovation Observatory Voice 0

Leave a Reply

Your email address will not be published. Required fields are marked *

Post Comment

Download Full Article



 

Connect to the Innovation Observatory

Twitter

Load More Related Posts

Get Alerts