LY-900014 (ultra-rapid lispro) is in development for the treatment of adult patients with type 1 diabetes mellitus. Type 1 diabetes mellitus is a condition which usually starts early in life and occurs as a result of the pancreas not producing enough (or sometimes any) insulin. This results in elevated blood sugar levels which can damage many organs in the body. Type 1 diabetes usually runs in families. While type 1 diabetes cannot be cured, having regular, at least daily, injections of insulin can keep blood sugar levels stable. However some people, despite having regular injections of insulin, still do not have stable blood sugar levels.
LY-900014 is a new formulation of insulin lispro that contains certain ingredients designed to increase the speed of insulin lispro absorption. Insulin lispro acts by copying the way naturally produced insulin works in people without diabetes. LY-900014 is administered by insulin pump and early studies have demonstrated rapid absorption of insulin lispro and improved glucose control after meals. If licensed, LY-900014 will offer a new option in insulin therapy for type 1 diabetes with the potential to help to keep blood sugar in range after eating.
Liraglutide acts like a hormone the body produces naturally that regulates appetite, known as glucagon-like-peptide (GLP-1). By activating areas of the brain that regulate appetite, liraglutide may decrease feelings of hunger which can lead to lower calorie intake and weight loss. If licensed, liraglutide may improve long-term outcomes for weight management in obese adolescents 12-17 years old who currently have limited treatment options.