This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Drugs > Nivolumab for high risk invasive urothelial carcinoma – adjuvant

< Back

Nivolumab for high risk invasive urothelial carcinoma – adjuvant


Cancer and Palliative Care

August 2019

Nivolumab is in development for the treatment of a type of bladder cancer that is at high risk of spreading beyond the lining of the bladder into the surrounding muscle. Bladder cancer starts when cells that make up the urinary bladder start to grow out of control. As more cancer cells develop, they can form a tumour and, with time, spread to other parts of the body. Urothelial cancer is the most common type of bladder cancer. High risk invasive urothelial cancer is when there is a greater chance for the cancer cells spreading to the lymph glands around the bladder and therefore patients have a reduced chance of cure.
Nivolumab, is a monoclonal antibody, a type of protein that has been designed to recognise and attach to a receptor (target) called PD-1 found on certain cells of the immune system called T cells. Cancer cells can produce proteins (PD-L1 and PD-L2) that attach to this receptor and switch off the activity of the T cells, preventing them from attacking the cancer. By attaching to the receptor, nivolumab prevents PD-L1 and PD-L2 from switching off the T cells, thereby increasing the ability of the immune system to kill cancer cells. If licenced for the adjuvant treatment of high risk invasive urothelial carcinoma, nivolumab has the potential to increase the length of time until the cancer comes back.

Innovation Observatory Voice 0

Leave a Reply

Your email address will not be published. Required fields are marked *

Post Comment

Download Full Article


Connect to the Innovation Observatory


Load More Related Posts

Get Alerts