Melanoma is a type of skin cancer that can appear anywhere on the body and usually begins with a mole. The back, legs and face are commonly affected areas of the body. Melanoma is the fifth most common cancer in the UK with a third of people diagnosed under the age of 55 years. Malignant melanoma indicates that the melanoma cells have spread deeper into the skin, lymph vessels or lymph glands close to the melanoma. Treatment of melanoma by surgery is often successful at first, but may begin to fail as the cancer spreads and enters end-stage disease. Treatments following tumour removal in malignant melanoma are not widely used in UK practice.
Seviprotimut-L is a type of cancer vaccine that is being developed for the treatment of adult patients with malignant melanoma who have had surgical resection. It is designed to stimulate the body’s immune system to fight cancer cells, to stop the cancer coming back. Seviprotimut-L is injected under the skin in different parts of the body. The unique way it acts may offer a new treatment option for malignant melanoma patients after surgery.
Selinexor is the first treatment option that targets XPO1, a protein that is responsible for exporting tumour suppressor proteins from the cell nucleus. It belongs to a new family of therapies called selective inhibition of nuclear export (SINE) compounds that blocks XPO1 leading to controlled death of myeloma cells. Currently there is no standard of care for the fifth line treatment of MM. Selinexor and low-dose dexamethasone are being developed as an oral treatment. If licensed, this combination could be an effective treatment option for a patient group with clear unmet need.