Melanoma is a type of skin cancer that can appear anywhere on the body and usually begins with a mole. The back, legs and face are commonly affected areas of the body. Melanoma is the fifth most common cancer in the UK with a third of people diagnosed under the age of 55 years. Malignant melanoma indicates that the melanoma cells have spread deeper into the skin, lymph vessels or lymph glands close to the melanoma. Treatment of melanoma by surgery is often successful at first, but may begin to fail as the cancer spreads and enters end-stage disease. Treatments following tumour removal in malignant melanoma are not widely used in UK practice.
Seviprotimut-L is a type of cancer vaccine that is being developed for the treatment of adult patients with malignant melanoma who have had surgical resection. It is designed to stimulate the body’s immune system to fight cancer cells, to stop the cancer coming back. Seviprotimut-L is injected under the skin in different parts of the body. The unique way it acts may offer a new treatment option for malignant melanoma patients after surgery.
Pembrolizumab, given by intravenous infusion, acts by binding to a protein called antiprogrammed death‐ligand 1 (PD‐L1) that is found on the cancer cells or immune cells trying
to attack cancer cells. Binding to this protein can lead to the activation of the body’s immune system to fight tumour cells. In cHL, pembrolizumab has promising results. If licensed it will
provide a treatment option for cHL patients who have failed ASCT or are not eligible for it.