Melanoma is a type of skin cancer that can appear anywhere on the body and usually begins with a mole. The back, legs and face are commonly affected areas of the body. Melanoma is the fifth most common cancer in the UK with a third of people diagnosed under the age of 55 years. Malignant melanoma indicates that the melanoma cells have spread deeper into the skin, lymph vessels or lymph glands close to the melanoma. Treatment of melanoma by surgery is often successful at first, but may begin to fail as the cancer spreads and enters end-stage disease. Treatments following tumour removal in malignant melanoma are not widely used in UK practice.
Seviprotimut-L is a type of cancer vaccine that is being developed for the treatment of adult patients with malignant melanoma who have had surgical resection. It is designed to stimulate the body’s immune system to fight cancer cells, to stop the cancer coming back. Seviprotimut-L is injected under the skin in different parts of the body. The unique way it acts may offer a new treatment option for malignant melanoma patients after surgery.
Nivolumab is a type of immunotherapy that is currently licensed in the UK for the treatment of several types of advanced cancers such as melanoma, non‐small cell lung cancer, and kidney cancer. It blocks a protein called programmed death-1 (PD-1), which is found on the surface of a type of immune cells called T-cells. Blocking PD-1 stimulates the T-cells to kill the cancer cells. Temozolomide in combination with radiotherapy is currently licensed in the UK for newly diagnosed glioblastoma in adults. The addition of nivolumab to temozolomide and radiotherapy will potentially offer an additional first line treatment option for adult patients who are newly diagnosed MGMT-methylated glioblastoma.