Budesonide-glycopyrronium-formoterol fumarate for the treatment of severe and inadequately controlled asthma

Budesonide-glycopyrronium-formoterol fumarate is in development for the treatment of severe asthma. Asthma is a common lung condition that causes occasional breathing difficulties. It affects people of all ages and often starts in childhood, although it can also develop for the first time in adults. Asthma is caused by swelling (inflammation) of the breathing tubes that carry air in and out of the lungs. This makes the tubes highly sensitive, so they temporarily narrow. It may happen randomly or after exposure to a trigger. Common asthma triggers include allergies, smoke, pollution and cold air, exercise, and infections like colds or flu. Severe asthma is asthma that does not respond well to regular asthma treatment. The main symptoms of asthma include breathlessness, coughing, wheezing, and a tight chest, and these symptoms can sometimes get temporarily worse (asthma attack).