Enfortumab vedotin in combination with pembrolizumab is in clinical development for the treatmentof patients with previously untreated locally advanced or metastatic urothelial cancer (UC). UC occurson the lining of the renal pelvis, ureter, bladder and urethra, and other parts of the urinary system.Metastatic UC occurs when the cancer has spread to other parts of the […]
Osimertinib is in development for the treatment of stage III, unresectable EGFR mutation positive non-small cell lung cancer (NSCLC) following definitive chemoradiation therapy. NSCLC is the most common form of lung cancer. Stage III lung cancer means the cancer is in more than one lobe of the lung, or it has spread to lymph nodes […]
Donanemab is currently in clinical development for the treatment of early Alzheimer’s disease(AD). AD is a progressive neurological disease which is caused by loss of function and death ofneurones in the brain. It is the most common type of dementia. One of the early symptoms of ADis mild cognitive impairment where a person may have […]
Selpercatinib is in clinical development for untreated advanced RET-fusion positive thyroid cancer in adults. Thyroid cancer is a rare form of cancer that originates in the thyroid gland located in the front of the neck. RET is a type of protein called a kinase, which is involved in various cell processes. RET-fusion positive cancer is […]
Benegrastim is being developed for the treatment of neutropenia in patients receiving chemotherapy treatment for breast cancer. Neutropenia occurs when an individual has low levels of neutrophils (a type of white blood cell), and it is a common side effect of cancer chemotherapy. Neutropenia can leave patients vulnerable to infections and cause complications such as […]
NIHR Innovation Observatory Insights share their ongoing methodological journey and learning experiences for building meaningful, inclusive engagement with children and families.
CAEL-101 is in clinical development for the treatment of amyloid light chain (AL) amyloidosis. AL amyloidosis belongs to a group of diseases called systemic amyloidosis in which deposits of proteins (called amyloids) accumulate and cause damage in tissues and organs, such as the kidneys, liver, gut, heart and nerves. In AL amyloidosis, the deposits are […]
Nemolizumab is currently in development for atopic dermatitis and prurigo nodularis. Atopic dermatitis is the most common form of eczema, a long-term (chronic) condition that causes patches of the skin to become itchy, dry and cracked. In moderate-to-severe cases, the patches cover a large area of the skin and can be associated with an intense […]
Letetresgene autoleucel is in clinical development for the treatment of advanced synovial sarcoma (SS) and myxoid/round cell liposarcoma (MRCLS) in children and adults. Both SS and MRCLS are two different types of soft tissue sarcomas, rare forms of cancer that develop in the tissues that connect, support, and surround other body structures and organs. Advanced […]
ADV7103 is currently in clinical development for the treatment of cystinuria in patients aged 1 year and above. Cystinuria is an inherited metabolic condition where irregular changes to genes called SLC3A1 and SLC7A9 results in abnormal transport of the amino acid, cysteine, in the kidney. This results in excessive amounts of cysteine excreted in the […]
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