Alpelisib is in development for the treatment of the rare disease PIK3CA-related overgrowth spectrum (PROS). PROS is a group of genetic conditions where parts of the body become abnormally overgrown and can affect anywhere from the limbs to the brain, resulting in a wide range of symptoms which can include: pain, fatigue, or seizures depending […]
Palbociclib in combination with trastuzumab with or without pertuzumab and endocrine therapy is currently in clinical development for use as a maintenance therapy for patients with hormone receptor positive (HR+) and human epidermal growth factor receptor 2 positive (HER2+) metastatic breast cancer who have had prior treatment. Breast cancer occurs when abnormal cells in the […]
Telisotuzumab vedotin is in development for the treatment of c-Met+ non-small cell lung cancer. Non-small cell lung cancer is the most common form of lung cancer. A c-Met is a protein in humans that is encoded by the MET gene that leads to growth in cells. Smoking is the cause of most lung cancers and […]
Invimestrocel is in clinical development for the treatment of acute ischaemic stroke within 18-36hours of onset. Ischaemic stroke is the most common type of stroke. It happens when a bloodvessel is blocked by a blood clot, cutting off blood flow to part of the brain (ischaemia). Withoutblood supply, brain cells can be damaged or destroyed […]
The project aimed to rapidly identify priority topic uncertainties as a first step to identify future systematic review questions of pertinence to key international faecal incontinence (FI) stakeholders (patients, carers, healthcare professionals, policy makers and voluntary, community or social enterprise representatives). The paper aim is to share our methods, experience and learning with other groups […]
We performed a systematic review of diagnostic test accuracy with the objective to assess the diagnostic accuracy of non-invasive or minimally invasive autopsy techniques in deaths under 1 year of age. MEDLINE (Ovid), EMBASE (Ovid), CINAHL (EBSCO), the Cochrane Library, Scopus and grey literature sources were searched from inception to November 2021. Studies were included if […]
Microservices and Serverless computing are promising cloud-based architectural models in the software development industry that have many advantages over previous technology models. The benefit of adopting these more novel models, however, is dependent on the volume of the application workload and the execution behavior. ScanMedicine is a new searching system dedicated to providing health care […]
There is need to consider the value of soft intelligence, leveraged using accessible natural language processing (NLP) tools, as a source of analysed evidence to support public health research outputs and decision-making. The aim of this study was to explore the value of soft intelligence analysed using NLP. As a case study, we selected and […]
To facilitate effective targeted COVID-19 vaccination strategies, it is important to understand reasons for vaccine hesitancy where uptake is low. Artificial intelligence (AI) techniques offer an opportunity for real-time analysis of public attitudes, sentiments, and key discussion topics from sources of soft-intelligence, including social media data. In this work, we explore the value of soft-intelligence, […]
New technologies continue to revolutionise the world as we have known it. There is no reason to think that early childhood will be spared this revolution. All indications are that technology companies, families, carers, and the education sector will continue to incorporate innovation into the lives of babies and young children around the globe. And yet the topic and the […]
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