Atezolizumab in combination with cabozantinib is in clinical development for the treatment of advanced renal cell carcinoma (RCC) after prior treatment. RCC (also called kidney cancer) is a disease that affects the lining of tiny tubes within the kidney which filter waste from the blood, making urine. In many cases of RCC there are no […]
Nivolumab and ipilimumab is in development for the first-line treatment of advanced hepatocellular carcinoma (HCC). HCC is the most common type of primary liver cancer, which affects men more than women, and is more likely to develop the older a person gets. Advanced HCC means the cancer is incurable. Symptoms include weight loss, jaundice (yellowing […]
Otilimab in combination with conventional synthetic disease-modifying antirheumatic drugs (DMARDs) is in clinical development for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA), who have had an inadequate response to conventional synthetic DMARDs and/or targeted therapies (biologic DMARDs and Janus Kinase inhibitors). RA is a chronic autoimmune condition where the […]
Neoadjuvant treatment of durvalumab in combination with gemcitabine-cisplatin and adjuvant treatment of durvalumab alone are currently in clinical development for patients with muscle-invasive bladder cancer (MIBC). Bladder cancer is where a growth of abnormal tissue, known as a tumour, develops in the bladder lining. When the cancerous cells spread beyond the lining, into the surrounding […]
Niraparib with abiraterone acetate and prednisone (AAP) is in clinical development for patients with prostate cancer which has spread from its original site (metastatic) and is untreatable via testosterone suppression therapy (castration resistant). Prostate cancer is a cancer of the prostate gland (a small organ in a man’s pelvis) and is the most common cancer […]
Letermovir is in clinical development for adult patients who have received a kidney transplant and are at risk of developing cytomegalovirus disease (CMV). CMV is normally a mild infection that causes flu-like symptoms but can be life-threatening in certain groups. Once infected with CMV, the virus stays in the body throughout a person’s life with […]
Efanesoctocog alfa is currently in clinical development for the treatment and prevention (prophylaxis) of bleeding episodes in patients with haemophilia A. Haemophilia A is a genetic bleeding disorder caused by a deficiency or absence of a blood clotting factor, called factor VIII (eight). This causes poor blood clotting, which results in difficulty in stopping the […]
Cholangiocarcinoma is a rare type of cancer that affects the bile ducts. Different subtypes of cholangiocarcinoma are classified by the location at which they develop in the biliary tract. Genetic changes (mutations) to the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) plays a central role in development of cholangiocarcinoma by contributing to the growth of abnormal […]
Enzalutamide is currently in clinical development for the treatment of high-risk non-metastatic prostate cancer (cancer that has not spread beyond the prostate) that has been previously treated with a radical prostatectomy (surgery to remove the prostate gland) and/or radiotherapy. Prostate cancer develops in the prostate gland and is the most common cancer in men in […]
Nivolumab in combination with ipilimumab is in clinical development as adjuvant therapy for adult patients with localised renal cell carcinoma (RCC) who underwent partial or entire removal of a kidney. RCC (the most common type of kidney cancer in adults) is a disease that affects the lining of tiny tubes within the kidney which filter […]
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