Bifikafusp alfa-onfekafusp alfa is currently in clinical development for the neoadjuvant treatment of resectable stage IIIB and IIIC melanoma. Melanoma is a type of skin cancer. The stage of a cancer tells how big it is and how far it has spread. Stage IIIB and IIIC melanomas are regional, meaning the cancer has spread beyond […]
Nivolumab is in clinical development as adjuvant therapy for adult patients with localised renal cell carcinoma (RCC) who underwent surgical removal of partial or entire of a kidney. RCC (the most common type of kidney cancer in adults) is a disease that affects the lining of tiny tubes within the kidney which filter waste from […]
Pembrolizumab in combination with paclitaxel with or without bevacizumab is in clinical development for the treatment of platinum-resistant recurrent ovarian cancer after one or two prior therapies. Ovarian cancer occurs when abnormal cells in the ovary begin to grow and divide in an uncontrolled way to eventually form a growth (tumour). Some of the symptoms […]
Tarlatamab is in clinical development for the treatment of adults with refractory (unresponsive to treatment) or relapsed small cell lung cancer (SCLC) who have progressed or recurred following one platinum-based (chemotherapy) regimen and at least a prior line of therapy. SCLC is a disease in which malignant (cancer) cells form in the tissues of the […]
Elinzanetant is in clinical development for the treatment of vasomotor symptoms (hot flashes) in women undergoing the menopause. The menopause occurs between 45 and 55 years of age and is caused by declining hormone levels. The declining hormone levels mean that neurons (nerve cells) in the hypothalamus (small part in the brain) become hyperactive and […]
Tezepelumab is in clinical development for the treatment of severe chronic rhinosinusitis with nasal polyps. Chronic rhinosinusitis is a condition in which the lining of the sinuses (air-filled spaces behind the nose, eyes, and cheeks) becomes inflamed for more than 12 weeks. People with the condition may have nasal polyps which are growths inside the […]
Mirvetuximab soravtansine is in clinical development for the treatment of adults with advanced, platinum-resistant, high-grade epithelial ovarian cancer, primary peritoneal cancer and fallopian tube cancer with high folate receptor-alpha expression. Epithelial ovarian cancer means the cancer started in the surface layer covering the ovary. The main symptoms are frequent swollen or bloated tummy, pain or […]
Vanzacaftor/tezacaftor/deutivacaftor is in development for the treatment of cystic fibrosis in patients with at least one F508del mutation (faulty gene). Cystic fibrosis is a rare, chronic, and life-shortening genetic disease caused by a faulty gene that affects the movement of salt and water in and out of cells. It is a progressive, multi-system disease that […]
Evolocumab is currently in clinical development for the prevention of major cardiovascular events in adults without prior heart attack or stroke who are at high risk of a cardiovascular event. Cardiovascular disease (CVD) is an umbrella term for all diseases of the heart and circulation. It includes everything from conditions that are inherited or that […]
Apremilast is being investigated for the treatment of moderate to severe plaque psoriasis in children and adolescents (aged 6 to 17 years old). Psoriasis is a skin disease that causes a rash with itchy, scaly patches, most commonly on the knees, elbows, trunk, and scalp. Plaque psoriasis is the most common, and is characterised by […]
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