The Innovation Observatory is a horizon scanning facility funded by the National Institute of Health and Social Care Research. Our goal is to identify new developments in medicines, technologies and care that could be used in the UK National Health Service, and to identify unmet health and care needs that future innovations could address.
AI interventions have enormous potential for improving the delivery of health and social care because of their ability to reduce the burden on healthcare systems by taking on tasks that can be converted into an algorithm. AI is most commonly applied to early detection and diagnosis, treatment, as well as outcome prediction and prognosis evaluation.
Atezolizumab in addition to paclitaxel and carboplatin is in clinical development for recurrent or primary advanced endometrial cancer (EC). EC (uterine cancer) is cancer of the lining of the womb. Recurrent cancer is cancer that has come back after treatment. Advanced cancer is cancer that cannot normally be cured or controlled. EC is characterised by […]
Enfortumab vedotin in combination with pembrolizumab is in clinical development as aneoadjuvant treatment option for cisplatin eligible patients with non-metastatic muscle invasivebladder cancer (MIBC). MIBC is a cancer that spreads into the muscle layer of the bladder wall.The survival rates for patients with MIBC are low because this type of cancer is more likely tospread […]
Botaretigene sparoparvovec is in development for the treatment of X-linked retinitis pigmentosa. Retinitis Pigmentosa (RP) is an inherited eye condition that affects the cells that line the back of the eye in the region known as the retina. RP is one of the most complicated genetic conditions, and over 80 causative genes have been identified. […]
Iptacopan is in development for the treatment of patients with complement 3 glomerulopathy (C3G) which is a rare disease. C3 is a blood protein that plays a key role in the normal immunity. The damaging build-up of the C3 protein in kidneys of patients with C3 glomerulopathy mostly results from dysregulation of the alternative complement […]
Upadacitinib is currently in clinical development for the treatment of giant cell arteritis (GCA) in adults aged 50 years and older. GCA is a disease of blood vessels where the arteries, particularly those in the neck and at the side of the head (the temples), become inflamed. Common symptoms include headaches with severe pain and […]
Neoadjuvant (before surgery) nivolumab in addition to gemcitabine and cisplatin followed by adjuvant (additional) nivolumab is in clinical development for muscle-invasive bladder cancer (MIBC). MIBC is when the cancer has spread beyond the lining of the bladder and into the muscle layer. The most well-known risk factor for MIBC is smoking, and the most common […]
Giroctocogene fitelparvovec is in development for the treatment of moderately severe to severehaemophilia A in adult males. Haemophilia A is a rare bleeding disorder, caused by lack of bloodclotting factor VIII which facilitates blood clotting and reduces bleeding events. The absence offactor VIII makes patients prone to excessive and uncontrolled bleeding. In severe cases, this […]
Sarilumab is currently in clinical development for the treatment of children and adolescents aged 2-17 with polyarticular Juvenile Idiopathic Arthritis (JIA) or oligoarticular extended JIA subtype. Arthritis is inflammation of the joints, and juvenile idiopathic arthritis means the arthritis of unknown origin present in children and adolescents. Symptoms of polyarticular JIA include joint pain, swelling […]
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