Pembrolizumab in combination with Bacillus Calmette-Guerin (BCG) is in development for the treatment of high-risk non-muscle invasive bladder cancer (NMIBC) that is recurrent or persistent following BCG induction or naïve to BCG treatment. Bladder cancer is when cancerous cells develop in the lining of the bladder. NMIBC is the most common type of bladder cancer […]
Cabotegravir is in clinical development as an alternative method of protecting an individual from contracting the human immunodeficiency virus type 1 (HIV-1). HIV is a chronic life altering condition that requires, daily antiretroviral therapy (ART) as a regular treatment routine. If left unmanaged it can lead to serious complications, such as acquired immunodeficiency syndrome (AIDS). […]
Linerixibat is in clinical development for the treatment of primary biliary cholangitis (PBC). PBC is a chronic autoimmune disease where bile (digestive fluid) flow from the liver is disrupted (i.e., cholestasis), resulting in excess bile acids in circulation. Cholestatic pruritus is an itch which is internal and cannot be relieved by scratching. The cause of […]
WP1048 is in clinical development for the treatment of adults with grass pollen allergy. Grass pollen allergy, also known as hay fever or allergic rhinitis, is caused by an immune reaction to proteins found in pollen from various types of grass. The allergy presents symptoms such as itchy eyes, blocked and inflamed nose and persistent […]
The Systematic Review (SR) Toolbox was developed in 2014 to collate tools that can be used to support the systematic review process but the breadth of evidence synthesis methodologies has expanded greatly since its inception. We updated the SR Toolbox in 2022 to reflect these changes and also briefly analysed included tools and guidance to […]
ScanMedicine is a novel searching system dedicated to providing health care professionals, patients, carers, the public, decision- and policy-makers, and researchers with open access to the development pipeline underpinning health technology innovations. In the first phase of developing ScanMedicine, we have focused on capturing and consolidating clinical trial records hosted on national and international clinical […]
In Oct/Nov 2020, prior to the availability of a vaccine, we conducted a survey on COVID-19 vaccine intention in adults living in England who either did not want or had not yet decided to be vaccinated against COVID-19. We asked the 1,660 participants “What might make it more likely that you, your family, or friends […]
Alpelisib is in development for the treatment of the rare disease PIK3CA-related overgrowth spectrum (PROS). PROS is a group of genetic conditions where parts of the body become abnormally overgrown and can affect anywhere from the limbs to the brain, resulting in a wide range of symptoms which can include: pain, fatigue, or seizures depending […]
Palbociclib in combination with trastuzumab with or without pertuzumab and endocrine therapy is currently in clinical development for use as a maintenance therapy for patients with hormone receptor positive (HR+) and human epidermal growth factor receptor 2 positive (HER2+) metastatic breast cancer who have had prior treatment. Breast cancer occurs when abnormal cells in the […]
Telisotuzumab vedotin is in development for the treatment of c-Met+ non-small cell lung cancer. Non-small cell lung cancer is the most common form of lung cancer. A c-Met is a protein in humans that is encoded by the MET gene that leads to growth in cells. Smoking is the cause of most lung cancers and […]
Subscribe to new content email alerts
Email *
Interested groups * Achondroplasia Activated PI3K delta syndrome Acute hepatic porphyria (AHP) Acute ischaemic stroke Acute lymphoblastic leukaemia (ALL) Acute myeloid leukaemia (AML) Adrenoleukodystrophy (ALD) Adrenomyeloneuropathy (AMN) Age-related macular degeneration (AMD) Alagille syndrome Alkaptonuria Alopecia areata Alport Syndrome Alzheimer's disease Amyloid light chain amyloidosis Amyloidosis Amyotrophic lateral sclerosis Anaemia Anaemia due to myelodysplastic syndromes (MDS) Anaemic myelofibrosis Anaesthesia Anal cancer Anaplastic astrocytoma Anaplastic large cell lymphoma (ALCL) Aneurysmal subarachnoid haemorrhage Angioimmunoblastic T-cell Lymphoma (AITL) Ankylosing spondylitis Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) Aromatic L-amino acid decarboxylase (AADC) deficiency Arterial venous access Articular cartilage defects Asthma Atopic dermatitis Atypical haemolytic uraemic syndrome (aHUS) Axial spondyloarthritis B-cell non-Hodgkin lymphoma Back pain Benign prostatic hyperplasia (BPH) Beta thalassemia Biliary tract cancer Bipolar disorder Bladder cancer Bladder pain syndrome Blastic plasmacytoid dendritic cell neoplasm (BPDCN) Bleeding Bone and Cartilage Cancer Bone sarcoma Breast cancer Calciphylaxis Cancer pain Cardiovascular disease (CVD) Cardiovascular events Cardiovascular System Cervical cancer Charcot-Marie-Tooth disease Chemoradiation-induced oral mucositis Chemotherapy-induced neutropenia Chemotherapy-induced thrombocytopenia Cholangiocarcinoma Choroideremia Chronic heart failure Chronic hepatitis D Chronic inducible cold urticaria Chronic kidney disease (CKD) Chronic lymphocytic leukaemia (CLL) Chronic myeloid leukaemia (CML) Chronic myelomonocytic leukaemia (CMML) Chronic obstructive pulmonary disease (COPD) Chronic spontaneous urticaria (CSU) Chronic thromboembolic pulmonary hypertension (CTEPH) Clostridioides difficile infection Cognitive impairment Cold agglutinin disease (CAD) Colon cancer Colorectal cancer Common cold Community-acquired pneumonia Complement 3 glomerulopathy Complex regional pain syndrome (CRPS) congenital ADAMTS-13 deficiency Congenital heart disease Congenital hyperinsulinism Critical limb ischaemia (CLI) Crohn's disease Cutaneous T-cell lymphoma (CTCL) Cystic fibrosis Cystinuria Cytomegalovirus (CMV) Delayed graft function (DGF) Dental and Oral Health Depression Dermatology Diabetic foot ulcer (DFU) Diabetic macular oedema Diabetic nephropathy Diabetic retinopathy Differentiated thyroid cancer (DTC) Diffuse large B-cell lymphoma (DLBCL) Distal renal tubular acidosis Duchenne muscular dystrophy (DMD) Dystrophic epidermolysis bullosa (DEB) Ear Endometrial cancer Endometriosis-associated pain Enthesitis-related arthritis Eosinophilic granulomatosis Eosinophilic granulomatosis with polyangiitis Eosinophilic oesophagitis Epilepsy Epithelial ovarian cancer Erectile dysfunction Erythropoietic protoporphyria Exocrine pancreatic insufficiency (EPI) Fabry disease Fallopian tube cancer Familial adenomatous polyposis (FAP) Familial primary hypoalphalipoproteinemia Fatal Female Reproductive Cancer Fibrodysplasia ossificans progressiva Focal segmental glomerulosclerosis (FSGS) Follicular lymphoma Gastric cancer Gastro-oesophageal junction adenocarcinoma Gastro-oesophageal junction cancer Gastrointestinal Cancer Gastrointestinal stromal tumour (GIST) Gaucher disease Generalised pustular psoriasis Generalised pustular psoriasis flares Genetic Disorders Geographic atrophy Giant cell arteritis Glaucoma Glioma Glucose transporter type 1 deficiency syndrome Graft versus host disease (GvHD) Granulomatosis with polyangiitis (GPA) Grass pollen allergy Gynaecology and Obstetrics Haemophilia A Haemophilia B Hand dysfunction Head and neck cancer Heart failure (HF) Heavy menstrual bleeding Hepatocellular carcinoma (HCC) Hereditary angioedema (HAE) Heterozygous familial hypercholesterolaemia (HeFH) Hidradenitis suppurativa (HS) High grade B cell lymphoma (HGBCL) HIV infection HIV-1 infection Hodgkin lymphoma Homozygous familial hypercholesterolemia Hospital-acquired pneumonia Hot flushes Huntington's disease Hyperargininemia Hypereosinophilic syndrome (HES) Hyperlipidaemia Hyperphagia Hypersomnia Hypertrophic cardiomyopathy (HCM) Hypoglycaemia Hypophosphataemia Hypoplasminogenaemia Idiopathic chronic cough Idiopathic inflammatory myopathies Idiopathic thrombocytopenic purpura IgA nephropathy Immune thrombocytopenia (ITP) Immunodeficiency Influenza Inherited epidermolysis bullosa (EB) Injured gluteal musculature Insomnia Interstitial cystitis Interstitial lung disease (ILD) Invasive candidasis Iron overload Irritable bowel syndrome with predominant constipation (IBS-C) Ischaemic stroke Juvenile idiopathic arthritis Juvenile psoriatic arthritis Leber's hereditary optic neuropathy (LHON) Lennox-Gastaut syndrome Leukocyte adhesion deficiency Long chain fatty acid oxidation disorders (LC-FAOD) Lower limb spasticity Lupus nephritis Lymphoblastic lymphoma (LBL) Lymphocytic colitis Major adverse cardiovascular events (MACE) Major cardiovascular events Major depressive disorder (MDD) Malignant pleural mesothelioma (MPM) Mantle cell lymphoma Marginal zone lymphoma (MZL) Mature T-cell lymphoma Medullary thyroid cancer (MTC) Melanoma Merkel cell carcinoma (MCC) Metabolic acidosis Metabolic Disorders Metachromatic leukodystrophy (MLD) Methotrexate toxicity during cancer therapy Microscopic polyangiitis (MPA) Migraine Mixed dyslipidaemia Molybdenum cofactor deficiency Type A Monocarboxylate transporter 8 deficiency (Allan-Herndon-Dudley syndrome) Motor neurone disease (MND or ALS) Mucopolysaccharidosis type IIIB (Sanfilippo B syndrome) Mucopolysaccharidosis type VII Multiple myeloma (MM) Multiple sclerosis (MS) Muscle spasticity Myasthenia gravis (MG) Myelodysplastic syndrome (MDS) Myelofibrosis Myeloproliferative Neoplasms Myofibroblastic tumour Myotonia Myotonic dystrophy Myxoid round cell liposarcoma Narcolepsy Nasal polyps Nasopharyngeal cancer Neovascular age-related macular degeneration Neuroblastoma Neurofibromatosis Neurogenic detrusor overactivity Neuromyelitis optica Neuromyelitis optica spectrum disorders Niemann-Pick Disease Nocturia Non-alcoholic steatohepatitis (NASH) Non-gBRCA mutated high-grade serous ovarian cancer Non-Hodgkin lymphoma (NHL) Non-malignant diseases Non-metastatic prostate cancer Non-small-cell lung cancer (NSCLC) Nose and Throat Obesity Obesity due to heart-failure Obesity due to Leptin receptor deficiency Obesity due to pro-opiomelanocortin deficiency Obesity-related heart failure Ocular hypertension Ocular inflammatory pain Oesophageal cancer Oesophageal squamous cell carcinoma Opioid dependence Opioid overdose Oral ulcers Orthostatic hypotension Osteoarthritic pain Osteomalacia Osteoporosis Ovarian cancer Ovarian function Painful bladder syndrome Pancreatic cancer Parkinson's disease Paroxysmal nocturnal haemoglobinuria Paroxysmal nocturnal haemoglobinuria (PNH) Peanut allergy Pemphigus vulgaris Peripheral arterial disease (PAD) Peripheral T-cell lymphoma (PTCL) PIK3CA-related overgrowth spectrum (PROS) Plaque psoriasis Polycythaemia vera Pompe disease Post-acute myocardial infarction (MI) Post-menopausal vasomotor symptoms Post-operative inflammation Post-operative pain Post-transplant lymphoproliferative disease (PTLD) Postmenopausal osteoporosis Postnatal depression Pouchitis Prevention of skeletal related events in multiple myeloma Primary biliary cholangitis (PBC) Primary generalised tonic-clonic seizures Primary haemophagocytic lymphohistiocytosis (HLH) Primary hypercholesterolaemia Primary hyperoxaluria Primary mediastinal large B-cell lymphoma (PMBCL) Primary open-angle glaucoma primary peritoneal cancer Primary sclerosing cholangitis (PSC) Procedural sedation Progeria Progressive familial intrahepatic cholestasis (PFIC) Progressive fibrosing interstitial lung disease (PF-ILD) Progressive supranuclear palsy (PSP) Prostate cancer Prurigo nodularis (PN) Pruritus Psoriatic arthritis Pulmonary arterial hypertension (PAH) Pyruvate kinase deficiency Regeneration of cartilage Renal anaemia Renal cell carcinoma (RCC) Renal disease Respiratory dysfunction Retinal Vein Occlusion Retinitis pigmentosa Retinopathy of prematurity Rett syndrome Rheumatoid arthritis Rhinosinusitis Schizophrenia Schnitzler syndrome Serious Trouble Short bowel syndrome Sialorrhea Sickle cell anaemia Sickle cell disease (SCD) Small lymphocytic lymphoma (SLL) Small-cell lung cancer (SCLC) Soft tissue sarcoma Solid tumours Spasmodic torticollis Spinal cord injury Spinal muscular atrophy (SMA) Spondyloarthritis Squamous cell carcinoma (SCC) Stroke Sudden sensorineural hearing loss Super-refractory status epilepticus (SRSE) Synovial sarcoma Systemic lupus erythematosus (SLE) Systemic mastocytosis Systemic sclerosis Tendon injury Tenosynovial giant cell tumour (TGCT) Thromboembolism Thrombotic microangiopathies Thrombotic thrombocytopenic purpura Thyroid cancer Transthyretin amyloid cardiomyopathy Traumatic brain injury (TBI) Tree pollen allergy Tuberous sclerosis Type 1 diabetes Type 2 diabetes Ulcerative colitis Ulcerative proctitis Uncontrolled bleeding Urinary incontinence Urothelial cancer Uterine Fibroids Uveal melanoma Venous leg ulcers Visual impairment Vitiligo Weight management WHIM syndrome Wilson's disease Wiskott-Aldrich syndrome (WAS) X-linked adrenoleukodystrophy (X-ALD) X-linked protoporphyria Check All
By clicking "subscribe" I confirm that I am happy to receive alerts.
Subscribed successfully.
