BI 1015550 is in clinical development for the treatment of idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF) in people aged 18 years and over. IPF is a long-term disease of the lungs characterised by the progressive deposition of collagen and fibrous tissue in the lungs. This causes the lung tissue to become inflamed […]
Dupilumab is currently in phase II/III development for adult patients with bullous pemphigoid (BP). BP is the most common form of blistering disorders of the skin. The first symptom of BP is usually redness and itching of the skin. BP primarily affects older people, with an average age around 80 years old. The burden of […]
Eplontersen is in clinical development for the treatment of adults with transthyretin amyloid cardiomyopathy (ATTR-CM). ATTR-CM occurs due to a build-up of abnormal proteins in the heart. These protein deposits can cause thickening and stiffening of the heart muscle, leading to heart failure. There are two types of ATTR, namely the hereditary and wild-type forms. […]
IgPro20 is in clinical development for the treatment of dermatomyositis (DM). DM is an inflammatory disease of the muscles and the skin which causes muscle weakness and severe skin rash. Although skeletal muscle and skin problems are the most frequent signs of the disease, inflammation may also affect the muscles of the oesophagus (the food […]
Troriluzole is in development for the treatment of adults with spinocerebellar ataxia (SCA). SCAs are a group of ataxias (lack of muscular control) which are inherited from parents. SCAs do not usually begin until adulthood and can affect people from the age of 25 up to 80, depending on the type of SCA. The symptoms […]
Inebilizumab is in clinical development for the treatment of adults with neuromyelitis optica spectrum disorder (NMOSD). NMOSD is a rare autoimmune condition in which the immune system attacks and damages one’s own spinal cord and optic nerves (nerves in the eyes). Autoantibodies (proteins that attacks own cells) against a cell surface protein found in neural […]
Brentuximab vedotin in combination with cyclophosphamide, prednisone and doxorubicin is in clinical development for the treatment of peripheral T-cell lymphoma (PTCL). Peripheral T-cell lymphomas (PTCLs) are a group of rare blood cancers. They develop in T-cells and affect the lymphatic system. PTCLs happen when the T-cells mutate and become cancerous cells that multiply uncontrollably. PTCL […]
Linaclotide acetate is currently in clinical development for the treatment of adults with chronic idiopathic constipation (CIC). Constipation is defecation that is problematic because of infrequent and/or hard stools, difficulty passing stools (often involving straining), or the sensation of incomplete emptying or anorectal blockage. Chronic is when the symptoms are present for at least three […]
Datopotamab deruxtecan is in development for the treatment of patients with previously untreated, locally recurrent inoperable or metastatic triple negative breast cancer (TNBC), who are not suitable candidates for PD-1/PD-L1 inhibitor therapy. TNBC is a subtype of breast cancer which lacks hormone receptor expression. The risk factors for TNBC include a history of breast disease […]
Sarconeos is currently in clinical development for treating adults aged 45 or over who are hospitalised with COVID-19. COVID-19 is an infectious respiratory disease caused by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). The main symptoms of COVID-19 are fever, a new continuous cough, and loss of taste or smell. In some patients, COVID-19 may […]
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