Dapsone is currently in clinical development for the treatment of COVID-19. COVID-19 is an infectious respiratory disease caused by the severe acute respiratory syndrome-coronavirus 2, SARS-CoV-2. The main symptoms of COVID-19 infection are fever, a new continuous cough, and loss of taste or smell. In some patients, COVID-19 may result in severe complications such as […]
Pitolisant is currently in clinical development for the treatment of narcolepsy with or without cataplexy in children and adolescents under the age of 18. Narcolepsy is a rare and long-term sleep disorder that affects the brain’s ability to regulate the normal sleep-wake cycle. Symptoms include excessive daytime sleepiness, sleep paralysis, hallucinations, and cataplexy – a […]
Ivacaftor is currently under clinical evaluation to assess its efficacy and safety in infants with cystic fibrosis (CF). CF is a life shortening, inherited condition that occurs due to a faulty gene called cystic fibrosis transmembrane conductance regulator (CFTR). When functioning properly, the CFTR gene should produce a protein which maintains a balance in salt […]
Lymphoma is a blood cancer which occurs if white blood cells of the immune system, grow and multiply uncontrollably. Twenty percent of all lymphoma patients are diagnosed with Hodgkin lymphoma. The disease usually occurs in individuals either aged between 20 to 25 or over 75 years. Symptoms include swelling of lymph nodes in the neck, […]
Ocrelizumab (subcutaneous) is in clinical development for the treatment of relapsing multiple sclerosis (MS) and primary progressive MS. MS is a condition where the body's immune system mistakenly attacks the nerves in the central nervous system which consists of the brain and spinal cord. This damage prevents messages travelling from the central nervous system (CNS) […]
Epcoritamab is currently in development for treatment of relapsed or refractory follicular lymphoma (FL). FL is a type of non-Hodgkin’s lymphoma (NHL) which affects white blood cells. In FL, the affected white blood cells start to multiply in an abnormal way and begin to aggregate in certain parts of the body such as the lymph […]
Venglustat is currently in clinical development for the treatment of adult and paediatric patients with GM2 gangliosidosis (which includes Tay-Sachs disease and its more severe form; Sandhoff disease) as well as other rare disorders including GM1 gangliosidosis, galactosialidosis and sialidosis. All these conditions are caused by genetic mutations involving a mechanism called the glucosylceramide-based sphingolipid […]
Marstacimab is in clinical development for the treatment of adults or adolescents with severe haemophilia A, and moderately severe to severe haemophilia B. Haemophilia is a rare, inherited condition that slows blood clotting. There are two main types of haemophilia: haemophilia A (a deficiency in clotting factor VIII) and haemophilia B (a deficiency in clotting […]
The Innovation Observatory is a horizon scanning facility funded by the National Institute of Health and Social Care Research. Our goal is to identify new developments in medicines, technologies and care that could be used in the UK National Health Service, and to identify unmet health and care needs that future innovations could address.
AZD3152 is currently in clinical development for the prevention of COVID-19. COVID-19 is an infectious respiratory disease caused by the severe acute respiratory syndrome-coronavirus 2, SARS-CoV-2. The main symptoms of COVID-19 infection are fever, a new continuous cough, and loss of taste or smell. In some patients, COVID-19 may result in severe complications such as […]
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