GISTs with D842V mutation in PDGFRA are usually resistant to the currently available targeted cancer drugs. Crenolanib is a medicine that specifically blocks the PDGFRA pathway involved in the production of blood vessels that supply the cancer cells, thereby preventing the cancer cells from growing and multiplying. It is being developed for the treatment of advanced or metastatic GISTs with D842V mutation in the PDGFRA gene. This drug is given by mouth. If licensed, crenolanib will offer an additional treatment option for this patient group, particularly those that do not respond to other treatments.