Guselkumab for treating ulcerative colitis

Guselkumab is in clinical development for the treatment of moderately to severely active ulcerative colitis (UC). UC is a long-term condition where parts of the large bowel become inflamed, causing urgent bloody diarrhoea and abdominal pain. The symptoms of UC often follow a pattern where individuals with the condition have periods of no symptoms or mild symptoms (remission) followed by periods where their symptoms are particularly troublesome (flare-ups or relapses). There are therapeutic options available for UC, however these are not effective in more than one third of patients and can be associated with adverse effects that limit their use.